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From Tumor Immunosuppression to Eradication: Targeting Homing and Activity of Immune Effector Cells to Tumors

Unraveling the mechanisms used by the immune system to fight cancer development is one of the most ambitious undertakings in immunology. Detailed knowledge regarding the mechanisms of induction of tolerance and immunosuppression within the tumor microenvironment will contribute to the development of...

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Detalles Bibliográficos
Autores principales: Draghiciu, Oana, Nijman, Hans W., Daemen, Toos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235497/
https://www.ncbi.nlm.nih.gov/pubmed/22190971
http://dx.doi.org/10.1155/2011/439053
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author Draghiciu, Oana
Nijman, Hans W.
Daemen, Toos
author_facet Draghiciu, Oana
Nijman, Hans W.
Daemen, Toos
author_sort Draghiciu, Oana
collection PubMed
description Unraveling the mechanisms used by the immune system to fight cancer development is one of the most ambitious undertakings in immunology. Detailed knowledge regarding the mechanisms of induction of tolerance and immunosuppression within the tumor microenvironment will contribute to the development of highly effective tumor eradication strategies. Research within the last few decades has shed more light on the matter. This paper aims to give an overview on the current knowledge of the main tolerance and immunosuppression mechanisms elicited within the tumor microenvironment, with the focus on development of effective immunotherapeutic strategies to improve homing and activity of immune effector cells to tumors.
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spelling pubmed-32354972011-12-21 From Tumor Immunosuppression to Eradication: Targeting Homing and Activity of Immune Effector Cells to Tumors Draghiciu, Oana Nijman, Hans W. Daemen, Toos Clin Dev Immunol Review Article Unraveling the mechanisms used by the immune system to fight cancer development is one of the most ambitious undertakings in immunology. Detailed knowledge regarding the mechanisms of induction of tolerance and immunosuppression within the tumor microenvironment will contribute to the development of highly effective tumor eradication strategies. Research within the last few decades has shed more light on the matter. This paper aims to give an overview on the current knowledge of the main tolerance and immunosuppression mechanisms elicited within the tumor microenvironment, with the focus on development of effective immunotherapeutic strategies to improve homing and activity of immune effector cells to tumors. Hindawi Publishing Corporation 2011 2011-12-08 /pmc/articles/PMC3235497/ /pubmed/22190971 http://dx.doi.org/10.1155/2011/439053 Text en Copyright © 2011 Oana Draghiciu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Draghiciu, Oana
Nijman, Hans W.
Daemen, Toos
From Tumor Immunosuppression to Eradication: Targeting Homing and Activity of Immune Effector Cells to Tumors
title From Tumor Immunosuppression to Eradication: Targeting Homing and Activity of Immune Effector Cells to Tumors
title_full From Tumor Immunosuppression to Eradication: Targeting Homing and Activity of Immune Effector Cells to Tumors
title_fullStr From Tumor Immunosuppression to Eradication: Targeting Homing and Activity of Immune Effector Cells to Tumors
title_full_unstemmed From Tumor Immunosuppression to Eradication: Targeting Homing and Activity of Immune Effector Cells to Tumors
title_short From Tumor Immunosuppression to Eradication: Targeting Homing and Activity of Immune Effector Cells to Tumors
title_sort from tumor immunosuppression to eradication: targeting homing and activity of immune effector cells to tumors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235497/
https://www.ncbi.nlm.nih.gov/pubmed/22190971
http://dx.doi.org/10.1155/2011/439053
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