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From Tumor Immunosuppression to Eradication: Targeting Homing and Activity of Immune Effector Cells to Tumors
Unraveling the mechanisms used by the immune system to fight cancer development is one of the most ambitious undertakings in immunology. Detailed knowledge regarding the mechanisms of induction of tolerance and immunosuppression within the tumor microenvironment will contribute to the development of...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235497/ https://www.ncbi.nlm.nih.gov/pubmed/22190971 http://dx.doi.org/10.1155/2011/439053 |
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author | Draghiciu, Oana Nijman, Hans W. Daemen, Toos |
author_facet | Draghiciu, Oana Nijman, Hans W. Daemen, Toos |
author_sort | Draghiciu, Oana |
collection | PubMed |
description | Unraveling the mechanisms used by the immune system to fight cancer development is one of the most ambitious undertakings in immunology. Detailed knowledge regarding the mechanisms of induction of tolerance and immunosuppression within the tumor microenvironment will contribute to the development of highly effective tumor eradication strategies. Research within the last few decades has shed more light on the matter. This paper aims to give an overview on the current knowledge of the main tolerance and immunosuppression mechanisms elicited within the tumor microenvironment, with the focus on development of effective immunotherapeutic strategies to improve homing and activity of immune effector cells to tumors. |
format | Online Article Text |
id | pubmed-3235497 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32354972011-12-21 From Tumor Immunosuppression to Eradication: Targeting Homing and Activity of Immune Effector Cells to Tumors Draghiciu, Oana Nijman, Hans W. Daemen, Toos Clin Dev Immunol Review Article Unraveling the mechanisms used by the immune system to fight cancer development is one of the most ambitious undertakings in immunology. Detailed knowledge regarding the mechanisms of induction of tolerance and immunosuppression within the tumor microenvironment will contribute to the development of highly effective tumor eradication strategies. Research within the last few decades has shed more light on the matter. This paper aims to give an overview on the current knowledge of the main tolerance and immunosuppression mechanisms elicited within the tumor microenvironment, with the focus on development of effective immunotherapeutic strategies to improve homing and activity of immune effector cells to tumors. Hindawi Publishing Corporation 2011 2011-12-08 /pmc/articles/PMC3235497/ /pubmed/22190971 http://dx.doi.org/10.1155/2011/439053 Text en Copyright © 2011 Oana Draghiciu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Draghiciu, Oana Nijman, Hans W. Daemen, Toos From Tumor Immunosuppression to Eradication: Targeting Homing and Activity of Immune Effector Cells to Tumors |
title | From Tumor Immunosuppression to Eradication: Targeting Homing and Activity of Immune Effector Cells to Tumors |
title_full | From Tumor Immunosuppression to Eradication: Targeting Homing and Activity of Immune Effector Cells to Tumors |
title_fullStr | From Tumor Immunosuppression to Eradication: Targeting Homing and Activity of Immune Effector Cells to Tumors |
title_full_unstemmed | From Tumor Immunosuppression to Eradication: Targeting Homing and Activity of Immune Effector Cells to Tumors |
title_short | From Tumor Immunosuppression to Eradication: Targeting Homing and Activity of Immune Effector Cells to Tumors |
title_sort | from tumor immunosuppression to eradication: targeting homing and activity of immune effector cells to tumors |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235497/ https://www.ncbi.nlm.nih.gov/pubmed/22190971 http://dx.doi.org/10.1155/2011/439053 |
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