Cargando…

MBL Interferes with Endovascular Trophoblast Invasion in Pre-Eclampsia

The spiral arteries undergo physiologic changes during pregnancy, and the failure of this process may lead to a spectrum of pregnancy disorders, including pre-eclampsia. Our recent data indicate that decidual endothelial cells (DECs), covering the inner side of the spiral arteries, acquire the abili...

Descripción completa

Detalles Bibliográficos
Autores principales: Agostinis, Chiara, Bossi, Fleur, Masat, Elisa, Radillo, Oriano, Tonon, Maddalena, De Seta, Francesco, Tedesco, Francesco, Bulla, Roberta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235499/
https://www.ncbi.nlm.nih.gov/pubmed/22203857
http://dx.doi.org/10.1155/2012/484321
_version_ 1782218611226574848
author Agostinis, Chiara
Bossi, Fleur
Masat, Elisa
Radillo, Oriano
Tonon, Maddalena
De Seta, Francesco
Tedesco, Francesco
Bulla, Roberta
author_facet Agostinis, Chiara
Bossi, Fleur
Masat, Elisa
Radillo, Oriano
Tonon, Maddalena
De Seta, Francesco
Tedesco, Francesco
Bulla, Roberta
author_sort Agostinis, Chiara
collection PubMed
description The spiral arteries undergo physiologic changes during pregnancy, and the failure of this process may lead to a spectrum of pregnancy disorders, including pre-eclampsia. Our recent data indicate that decidual endothelial cells (DECs), covering the inner side of the spiral arteries, acquire the ability to synthesize C1q, which acts as a link between endovascular trophoblast and DECs favouring the process of vascular remodelling. In this study, we have shown that sera obtained from pre-eclamptic patients strongly inhibit the interaction between extravillous trophoblast (EVT) and DECs, preventing endovascular invasion of trophoblast cells. We further demonstrated that mannose-binding lectin (MBL), one of the factor increased in pre-eclamptic patient sera, strongly inhibits the interaction of EVT with C1q interfering with the process of EVT adhesion to and migration through DECs. These data suggest that the increased level of MBL in pre-eclampsia may contribute to the failure of the endovascular invasion of trophoblast cells.
format Online
Article
Text
id pubmed-3235499
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-32354992011-12-27 MBL Interferes with Endovascular Trophoblast Invasion in Pre-Eclampsia Agostinis, Chiara Bossi, Fleur Masat, Elisa Radillo, Oriano Tonon, Maddalena De Seta, Francesco Tedesco, Francesco Bulla, Roberta Clin Dev Immunol Research Article The spiral arteries undergo physiologic changes during pregnancy, and the failure of this process may lead to a spectrum of pregnancy disorders, including pre-eclampsia. Our recent data indicate that decidual endothelial cells (DECs), covering the inner side of the spiral arteries, acquire the ability to synthesize C1q, which acts as a link between endovascular trophoblast and DECs favouring the process of vascular remodelling. In this study, we have shown that sera obtained from pre-eclamptic patients strongly inhibit the interaction between extravillous trophoblast (EVT) and DECs, preventing endovascular invasion of trophoblast cells. We further demonstrated that mannose-binding lectin (MBL), one of the factor increased in pre-eclamptic patient sera, strongly inhibits the interaction of EVT with C1q interfering with the process of EVT adhesion to and migration through DECs. These data suggest that the increased level of MBL in pre-eclampsia may contribute to the failure of the endovascular invasion of trophoblast cells. Hindawi Publishing Corporation 2012 2011-12-06 /pmc/articles/PMC3235499/ /pubmed/22203857 http://dx.doi.org/10.1155/2012/484321 Text en Copyright © 2012 Chiara Agostinis et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Agostinis, Chiara
Bossi, Fleur
Masat, Elisa
Radillo, Oriano
Tonon, Maddalena
De Seta, Francesco
Tedesco, Francesco
Bulla, Roberta
MBL Interferes with Endovascular Trophoblast Invasion in Pre-Eclampsia
title MBL Interferes with Endovascular Trophoblast Invasion in Pre-Eclampsia
title_full MBL Interferes with Endovascular Trophoblast Invasion in Pre-Eclampsia
title_fullStr MBL Interferes with Endovascular Trophoblast Invasion in Pre-Eclampsia
title_full_unstemmed MBL Interferes with Endovascular Trophoblast Invasion in Pre-Eclampsia
title_short MBL Interferes with Endovascular Trophoblast Invasion in Pre-Eclampsia
title_sort mbl interferes with endovascular trophoblast invasion in pre-eclampsia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235499/
https://www.ncbi.nlm.nih.gov/pubmed/22203857
http://dx.doi.org/10.1155/2012/484321
work_keys_str_mv AT agostinischiara mblinterfereswithendovasculartrophoblastinvasioninpreeclampsia
AT bossifleur mblinterfereswithendovasculartrophoblastinvasioninpreeclampsia
AT masatelisa mblinterfereswithendovasculartrophoblastinvasioninpreeclampsia
AT radillooriano mblinterfereswithendovasculartrophoblastinvasioninpreeclampsia
AT tononmaddalena mblinterfereswithendovasculartrophoblastinvasioninpreeclampsia
AT desetafrancesco mblinterfereswithendovasculartrophoblastinvasioninpreeclampsia
AT tedescofrancesco mblinterfereswithendovasculartrophoblastinvasioninpreeclampsia
AT bullaroberta mblinterfereswithendovasculartrophoblastinvasioninpreeclampsia