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RAM/Fam103a1 Is Required for mRNA Cap Methylation

The 7-methylguanosine cap added to the 5′ end of mRNA is required for efficient gene expression in eukaryotes. In mammals, methylation of the guanosine cap is catalyzed by RNMT (RNA guanine-7 methyltransferase), an enzyme previously thought to function as a monomer. We have identified an obligate co...

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Detalles Bibliográficos
Autores principales:	Gonatopoulos-Pournatzis, Thomas, Dunn, Sianadh, Bounds, Rebecca, Cowling, Victoria H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235549/ https://www.ncbi.nlm.nih.gov/pubmed/22099306 http://dx.doi.org/10.1016/j.molcel.2011.08.041

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