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Harnessing dendritic cells in inflammatory skin diseases

The skin immune system harbors a complex network of dendritic cells (DCs). Recent studies highlight a diverse functional specialization of skin DC subsets. In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms to ensure the mainten...

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Detalles Bibliográficos
Autores principales: Chu, Chung-Ching, Di Meglio, Paola, Nestle, Frank O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235550/
https://www.ncbi.nlm.nih.gov/pubmed/21295490
http://dx.doi.org/10.1016/j.smim.2011.01.006
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author Chu, Chung-Ching
Di Meglio, Paola
Nestle, Frank O.
author_facet Chu, Chung-Ching
Di Meglio, Paola
Nestle, Frank O.
author_sort Chu, Chung-Ching
collection PubMed
description The skin immune system harbors a complex network of dendritic cells (DCs). Recent studies highlight a diverse functional specialization of skin DC subsets. In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms to ensure the maintenance of immune homeostasis, as well as in pathogenesis of chronic inflammation in the skin when excessive immune responses are initiated and unrestrained. Harnessing DCs by directly targeting DC-derived molecules or selectively modulate DC subsets is a convincing strategy to tackle inflammatory skin diseases. In this review we discuss recent advances underlining the functional specialization of skin DCs and discuss the potential implication for future DC-based therapeutic strategies.
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spelling pubmed-32355502011-12-28 Harnessing dendritic cells in inflammatory skin diseases Chu, Chung-Ching Di Meglio, Paola Nestle, Frank O. Semin Immunol Review The skin immune system harbors a complex network of dendritic cells (DCs). Recent studies highlight a diverse functional specialization of skin DC subsets. In addition to generating cellular and humoral immunity against pathogens, skin DCs are involved in tolerogenic mechanisms to ensure the maintenance of immune homeostasis, as well as in pathogenesis of chronic inflammation in the skin when excessive immune responses are initiated and unrestrained. Harnessing DCs by directly targeting DC-derived molecules or selectively modulate DC subsets is a convincing strategy to tackle inflammatory skin diseases. In this review we discuss recent advances underlining the functional specialization of skin DCs and discuss the potential implication for future DC-based therapeutic strategies. Academic Press 2011-02 /pmc/articles/PMC3235550/ /pubmed/21295490 http://dx.doi.org/10.1016/j.smim.2011.01.006 Text en © 2011 Elsevier Ltd. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Review
Chu, Chung-Ching
Di Meglio, Paola
Nestle, Frank O.
Harnessing dendritic cells in inflammatory skin diseases
title Harnessing dendritic cells in inflammatory skin diseases
title_full Harnessing dendritic cells in inflammatory skin diseases
title_fullStr Harnessing dendritic cells in inflammatory skin diseases
title_full_unstemmed Harnessing dendritic cells in inflammatory skin diseases
title_short Harnessing dendritic cells in inflammatory skin diseases
title_sort harnessing dendritic cells in inflammatory skin diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235550/
https://www.ncbi.nlm.nih.gov/pubmed/21295490
http://dx.doi.org/10.1016/j.smim.2011.01.006
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