Cargando…

Thigmotropism of Malignant Melanoma Cells

During malignant melanoma (MM) progression including incipient metastasis, neoplastic cells follow some specific migration paths inside the skin. In particular, they progress along the dermoepidermal basement membrane, the hair follicles, the sweat gland apparatus, nerves, and the near perivascular...

Descripción completa

Detalles Bibliográficos
Autores principales: Quatresooz, Pascale, Piérard-Franchimont, Claudine, Noël, Fanchon, Piérard, Gérald E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235666/
https://www.ncbi.nlm.nih.gov/pubmed/22203839
http://dx.doi.org/10.1155/2012/362784
_version_ 1782218625544880128
author Quatresooz, Pascale
Piérard-Franchimont, Claudine
Noël, Fanchon
Piérard, Gérald E.
author_facet Quatresooz, Pascale
Piérard-Franchimont, Claudine
Noël, Fanchon
Piérard, Gérald E.
author_sort Quatresooz, Pascale
collection PubMed
description During malignant melanoma (MM) progression including incipient metastasis, neoplastic cells follow some specific migration paths inside the skin. In particular, they progress along the dermoepidermal basement membrane, the hair follicles, the sweat gland apparatus, nerves, and the near perivascular space. These features evoke the thigmotropism phenomenon defined as a contact-sensing growth of cells. This process is likely connected to modulation in cell tensegrity (control of the cell shape). These specifically located paucicellular aggregates of MM cells do not appear to be involved in the tumorigenic growth phase, but rather they participate in the so-called “accretive” growth model. These MM cell collections are often part of the primary neoplasm, but they may, however, correspond to MM micrometastases and predict further local overt metastasis spread.
format Online
Article
Text
id pubmed-3235666
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-32356662011-12-27 Thigmotropism of Malignant Melanoma Cells Quatresooz, Pascale Piérard-Franchimont, Claudine Noël, Fanchon Piérard, Gérald E. Dermatol Res Pract Review Article During malignant melanoma (MM) progression including incipient metastasis, neoplastic cells follow some specific migration paths inside the skin. In particular, they progress along the dermoepidermal basement membrane, the hair follicles, the sweat gland apparatus, nerves, and the near perivascular space. These features evoke the thigmotropism phenomenon defined as a contact-sensing growth of cells. This process is likely connected to modulation in cell tensegrity (control of the cell shape). These specifically located paucicellular aggregates of MM cells do not appear to be involved in the tumorigenic growth phase, but rather they participate in the so-called “accretive” growth model. These MM cell collections are often part of the primary neoplasm, but they may, however, correspond to MM micrometastases and predict further local overt metastasis spread. Hindawi Publishing Corporation 2012 2011-11-17 /pmc/articles/PMC3235666/ /pubmed/22203839 http://dx.doi.org/10.1155/2012/362784 Text en Copyright © 2012 Pascale Quatresooz et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Quatresooz, Pascale
Piérard-Franchimont, Claudine
Noël, Fanchon
Piérard, Gérald E.
Thigmotropism of Malignant Melanoma Cells
title Thigmotropism of Malignant Melanoma Cells
title_full Thigmotropism of Malignant Melanoma Cells
title_fullStr Thigmotropism of Malignant Melanoma Cells
title_full_unstemmed Thigmotropism of Malignant Melanoma Cells
title_short Thigmotropism of Malignant Melanoma Cells
title_sort thigmotropism of malignant melanoma cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235666/
https://www.ncbi.nlm.nih.gov/pubmed/22203839
http://dx.doi.org/10.1155/2012/362784
work_keys_str_mv AT quatresoozpascale thigmotropismofmalignantmelanomacells
AT pierardfranchimontclaudine thigmotropismofmalignantmelanomacells
AT noelfanchon thigmotropismofmalignantmelanomacells
AT pierardgeralde thigmotropismofmalignantmelanomacells