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Thigmotropism of Malignant Melanoma Cells
During malignant melanoma (MM) progression including incipient metastasis, neoplastic cells follow some specific migration paths inside the skin. In particular, they progress along the dermoepidermal basement membrane, the hair follicles, the sweat gland apparatus, nerves, and the near perivascular...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235666/ https://www.ncbi.nlm.nih.gov/pubmed/22203839 http://dx.doi.org/10.1155/2012/362784 |
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author | Quatresooz, Pascale Piérard-Franchimont, Claudine Noël, Fanchon Piérard, Gérald E. |
author_facet | Quatresooz, Pascale Piérard-Franchimont, Claudine Noël, Fanchon Piérard, Gérald E. |
author_sort | Quatresooz, Pascale |
collection | PubMed |
description | During malignant melanoma (MM) progression including incipient metastasis, neoplastic cells follow some specific migration paths inside the skin. In particular, they progress along the dermoepidermal basement membrane, the hair follicles, the sweat gland apparatus, nerves, and the near perivascular space. These features evoke the thigmotropism phenomenon defined as a contact-sensing growth of cells. This process is likely connected to modulation in cell tensegrity (control of the cell shape). These specifically located paucicellular aggregates of MM cells do not appear to be involved in the tumorigenic growth phase, but rather they participate in the so-called “accretive” growth model. These MM cell collections are often part of the primary neoplasm, but they may, however, correspond to MM micrometastases and predict further local overt metastasis spread. |
format | Online Article Text |
id | pubmed-3235666 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32356662011-12-27 Thigmotropism of Malignant Melanoma Cells Quatresooz, Pascale Piérard-Franchimont, Claudine Noël, Fanchon Piérard, Gérald E. Dermatol Res Pract Review Article During malignant melanoma (MM) progression including incipient metastasis, neoplastic cells follow some specific migration paths inside the skin. In particular, they progress along the dermoepidermal basement membrane, the hair follicles, the sweat gland apparatus, nerves, and the near perivascular space. These features evoke the thigmotropism phenomenon defined as a contact-sensing growth of cells. This process is likely connected to modulation in cell tensegrity (control of the cell shape). These specifically located paucicellular aggregates of MM cells do not appear to be involved in the tumorigenic growth phase, but rather they participate in the so-called “accretive” growth model. These MM cell collections are often part of the primary neoplasm, but they may, however, correspond to MM micrometastases and predict further local overt metastasis spread. Hindawi Publishing Corporation 2012 2011-11-17 /pmc/articles/PMC3235666/ /pubmed/22203839 http://dx.doi.org/10.1155/2012/362784 Text en Copyright © 2012 Pascale Quatresooz et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Quatresooz, Pascale Piérard-Franchimont, Claudine Noël, Fanchon Piérard, Gérald E. Thigmotropism of Malignant Melanoma Cells |
title | Thigmotropism of Malignant Melanoma Cells |
title_full | Thigmotropism of Malignant Melanoma Cells |
title_fullStr | Thigmotropism of Malignant Melanoma Cells |
title_full_unstemmed | Thigmotropism of Malignant Melanoma Cells |
title_short | Thigmotropism of Malignant Melanoma Cells |
title_sort | thigmotropism of malignant melanoma cells |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235666/ https://www.ncbi.nlm.nih.gov/pubmed/22203839 http://dx.doi.org/10.1155/2012/362784 |
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