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Reactive Oxygen Species in Skeletal Muscle Signaling
Generation of reactive oxygen species (ROS) is a ubiquitous phenomenon in eukaryotic cells' life. Up to the 1990s of the past century, ROS have been solely considered as toxic species resulting in oxidative stress, pathogenesis and aging. However, there is now clear evidence that ROS are not me...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235811/ https://www.ncbi.nlm.nih.gov/pubmed/22175016 http://dx.doi.org/10.1155/2012/982794 |
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author | Barbieri, Elena Sestili, Piero |
author_facet | Barbieri, Elena Sestili, Piero |
author_sort | Barbieri, Elena |
collection | PubMed |
description | Generation of reactive oxygen species (ROS) is a ubiquitous phenomenon in eukaryotic cells' life. Up to the 1990s of the past century, ROS have been solely considered as toxic species resulting in oxidative stress, pathogenesis and aging. However, there is now clear evidence that ROS are not merely toxic species but also—within certain concentrations—useful signaling molecules regulating physiological processes. During intense skeletal muscle contractile activity myotubes' mitochondria generate high ROS flows: this renders skeletal muscle a tissue where ROS hold a particular relevance. According to their hormetic nature, in muscles ROS may trigger different signaling pathways leading to diverging responses, from adaptation to cell death. Whether a “positive” or “negative” response will prevail depends on many variables such as, among others, the site of ROS production, the persistence of ROS flow or target cells' antioxidant status. In this light, a specific threshold of physiological ROS concentrations above which ROS exert negative, toxic effects is hard to determine, and the concept of “physiologically compatible” levels of ROS would better fit with such a dynamic scenario. In this review these concepts will be discussed along with the most relevant signaling pathways triggered and/or affected by ROS in skeletal muscle. |
format | Online Article Text |
id | pubmed-3235811 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32358112011-12-15 Reactive Oxygen Species in Skeletal Muscle Signaling Barbieri, Elena Sestili, Piero J Signal Transduct Review Article Generation of reactive oxygen species (ROS) is a ubiquitous phenomenon in eukaryotic cells' life. Up to the 1990s of the past century, ROS have been solely considered as toxic species resulting in oxidative stress, pathogenesis and aging. However, there is now clear evidence that ROS are not merely toxic species but also—within certain concentrations—useful signaling molecules regulating physiological processes. During intense skeletal muscle contractile activity myotubes' mitochondria generate high ROS flows: this renders skeletal muscle a tissue where ROS hold a particular relevance. According to their hormetic nature, in muscles ROS may trigger different signaling pathways leading to diverging responses, from adaptation to cell death. Whether a “positive” or “negative” response will prevail depends on many variables such as, among others, the site of ROS production, the persistence of ROS flow or target cells' antioxidant status. In this light, a specific threshold of physiological ROS concentrations above which ROS exert negative, toxic effects is hard to determine, and the concept of “physiologically compatible” levels of ROS would better fit with such a dynamic scenario. In this review these concepts will be discussed along with the most relevant signaling pathways triggered and/or affected by ROS in skeletal muscle. Hindawi Publishing Corporation 2012 2011-12-05 /pmc/articles/PMC3235811/ /pubmed/22175016 http://dx.doi.org/10.1155/2012/982794 Text en Copyright © 2012 E. Barbieri and P. Sestili. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Barbieri, Elena Sestili, Piero Reactive Oxygen Species in Skeletal Muscle Signaling |
title | Reactive Oxygen Species in Skeletal Muscle Signaling |
title_full | Reactive Oxygen Species in Skeletal Muscle Signaling |
title_fullStr | Reactive Oxygen Species in Skeletal Muscle Signaling |
title_full_unstemmed | Reactive Oxygen Species in Skeletal Muscle Signaling |
title_short | Reactive Oxygen Species in Skeletal Muscle Signaling |
title_sort | reactive oxygen species in skeletal muscle signaling |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235811/ https://www.ncbi.nlm.nih.gov/pubmed/22175016 http://dx.doi.org/10.1155/2012/982794 |
work_keys_str_mv | AT barbierielena reactiveoxygenspeciesinskeletalmusclesignaling AT sestilipiero reactiveoxygenspeciesinskeletalmusclesignaling |