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Reactive Oxygen Species in Skeletal Muscle Signaling

Generation of reactive oxygen species (ROS) is a ubiquitous phenomenon in eukaryotic cells' life. Up to the 1990s of the past century, ROS have been solely considered as toxic species resulting in oxidative stress, pathogenesis and aging. However, there is now clear evidence that ROS are not me...

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Detalles Bibliográficos
Autores principales: Barbieri, Elena, Sestili, Piero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235811/
https://www.ncbi.nlm.nih.gov/pubmed/22175016
http://dx.doi.org/10.1155/2012/982794
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author Barbieri, Elena
Sestili, Piero
author_facet Barbieri, Elena
Sestili, Piero
author_sort Barbieri, Elena
collection PubMed
description Generation of reactive oxygen species (ROS) is a ubiquitous phenomenon in eukaryotic cells' life. Up to the 1990s of the past century, ROS have been solely considered as toxic species resulting in oxidative stress, pathogenesis and aging. However, there is now clear evidence that ROS are not merely toxic species but also—within certain concentrations—useful signaling molecules regulating physiological processes. During intense skeletal muscle contractile activity myotubes' mitochondria generate high ROS flows: this renders skeletal muscle a tissue where ROS hold a particular relevance. According to their hormetic nature, in muscles ROS may trigger different signaling pathways leading to diverging responses, from adaptation to cell death. Whether a “positive” or “negative” response will prevail depends on many variables such as, among others, the site of ROS production, the persistence of ROS flow or target cells' antioxidant status. In this light, a specific threshold of physiological ROS concentrations above which ROS exert negative, toxic effects is hard to determine, and the concept of “physiologically compatible” levels of ROS would better fit with such a dynamic scenario. In this review these concepts will be discussed along with the most relevant signaling pathways triggered and/or affected by ROS in skeletal muscle.
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spelling pubmed-32358112011-12-15 Reactive Oxygen Species in Skeletal Muscle Signaling Barbieri, Elena Sestili, Piero J Signal Transduct Review Article Generation of reactive oxygen species (ROS) is a ubiquitous phenomenon in eukaryotic cells' life. Up to the 1990s of the past century, ROS have been solely considered as toxic species resulting in oxidative stress, pathogenesis and aging. However, there is now clear evidence that ROS are not merely toxic species but also—within certain concentrations—useful signaling molecules regulating physiological processes. During intense skeletal muscle contractile activity myotubes' mitochondria generate high ROS flows: this renders skeletal muscle a tissue where ROS hold a particular relevance. According to their hormetic nature, in muscles ROS may trigger different signaling pathways leading to diverging responses, from adaptation to cell death. Whether a “positive” or “negative” response will prevail depends on many variables such as, among others, the site of ROS production, the persistence of ROS flow or target cells' antioxidant status. In this light, a specific threshold of physiological ROS concentrations above which ROS exert negative, toxic effects is hard to determine, and the concept of “physiologically compatible” levels of ROS would better fit with such a dynamic scenario. In this review these concepts will be discussed along with the most relevant signaling pathways triggered and/or affected by ROS in skeletal muscle. Hindawi Publishing Corporation 2012 2011-12-05 /pmc/articles/PMC3235811/ /pubmed/22175016 http://dx.doi.org/10.1155/2012/982794 Text en Copyright © 2012 E. Barbieri and P. Sestili. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Barbieri, Elena
Sestili, Piero
Reactive Oxygen Species in Skeletal Muscle Signaling
title Reactive Oxygen Species in Skeletal Muscle Signaling
title_full Reactive Oxygen Species in Skeletal Muscle Signaling
title_fullStr Reactive Oxygen Species in Skeletal Muscle Signaling
title_full_unstemmed Reactive Oxygen Species in Skeletal Muscle Signaling
title_short Reactive Oxygen Species in Skeletal Muscle Signaling
title_sort reactive oxygen species in skeletal muscle signaling
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235811/
https://www.ncbi.nlm.nih.gov/pubmed/22175016
http://dx.doi.org/10.1155/2012/982794
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