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Relationship between DNA Mismatch Repair Deficiency and Endometrial Cancer
Some cases of endometrial cancer are associated with a familial tumor and are referred to as hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome). Lynch syndrome is thought to be induced by germline mutation of the DNA mismatch repair (MMR) gene. An aberration in the MMR gene prevents...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235885/ https://www.ncbi.nlm.nih.gov/pubmed/22175017 http://dx.doi.org/10.4061/2011/256063 |
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author | Masuda, Kenta Banno, Kouji Yanokura, Megumi Kobayashi, Yusuke Kisu, Iori Ueki, Arisa Ono, Asuka Asahara, Nana Nomura, Hiroyuki Hirasawa, Akira Susumu, Nobuyuki Aoki, Daisuke |
author_facet | Masuda, Kenta Banno, Kouji Yanokura, Megumi Kobayashi, Yusuke Kisu, Iori Ueki, Arisa Ono, Asuka Asahara, Nana Nomura, Hiroyuki Hirasawa, Akira Susumu, Nobuyuki Aoki, Daisuke |
author_sort | Masuda, Kenta |
collection | PubMed |
description | Some cases of endometrial cancer are associated with a familial tumor and are referred to as hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome). Lynch syndrome is thought to be induced by germline mutation of the DNA mismatch repair (MMR) gene. An aberration in the MMR gene prevents accurate repair of base mismatches produced during DNA replication. This phenomenon can lead to an increased frequency of errors in target genes involved in carcinogenesis, resulting in cancerization of the cell. On the other hand, aberrant DNA methylation is thought to play a key role in sporadic endometrial carcinogenesis. Hypermethylation of unmethylated CpG islands in the promoter regions of cancer-related genes associated with DNA repair leads to the cell becoming cancerous. Thus, both genetic and epigenetic changes are intricately involved in the process through which cells become cancerous. In this review, we introduce the latest findings on the DNA mismatch repair pathway in endometrial cancer. |
format | Online Article Text |
id | pubmed-3235885 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-32358852011-12-15 Relationship between DNA Mismatch Repair Deficiency and Endometrial Cancer Masuda, Kenta Banno, Kouji Yanokura, Megumi Kobayashi, Yusuke Kisu, Iori Ueki, Arisa Ono, Asuka Asahara, Nana Nomura, Hiroyuki Hirasawa, Akira Susumu, Nobuyuki Aoki, Daisuke Mol Biol Int Review Article Some cases of endometrial cancer are associated with a familial tumor and are referred to as hereditary nonpolyposis colorectal cancer (HNPCC or Lynch syndrome). Lynch syndrome is thought to be induced by germline mutation of the DNA mismatch repair (MMR) gene. An aberration in the MMR gene prevents accurate repair of base mismatches produced during DNA replication. This phenomenon can lead to an increased frequency of errors in target genes involved in carcinogenesis, resulting in cancerization of the cell. On the other hand, aberrant DNA methylation is thought to play a key role in sporadic endometrial carcinogenesis. Hypermethylation of unmethylated CpG islands in the promoter regions of cancer-related genes associated with DNA repair leads to the cell becoming cancerous. Thus, both genetic and epigenetic changes are intricately involved in the process through which cells become cancerous. In this review, we introduce the latest findings on the DNA mismatch repair pathway in endometrial cancer. SAGE-Hindawi Access to Research 2011 2011-12-08 /pmc/articles/PMC3235885/ /pubmed/22175017 http://dx.doi.org/10.4061/2011/256063 Text en Copyright © 2011 Kenta Masuda et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Masuda, Kenta Banno, Kouji Yanokura, Megumi Kobayashi, Yusuke Kisu, Iori Ueki, Arisa Ono, Asuka Asahara, Nana Nomura, Hiroyuki Hirasawa, Akira Susumu, Nobuyuki Aoki, Daisuke Relationship between DNA Mismatch Repair Deficiency and Endometrial Cancer |
title | Relationship between DNA Mismatch Repair Deficiency and Endometrial Cancer |
title_full | Relationship between DNA Mismatch Repair Deficiency and Endometrial Cancer |
title_fullStr | Relationship between DNA Mismatch Repair Deficiency and Endometrial Cancer |
title_full_unstemmed | Relationship between DNA Mismatch Repair Deficiency and Endometrial Cancer |
title_short | Relationship between DNA Mismatch Repair Deficiency and Endometrial Cancer |
title_sort | relationship between dna mismatch repair deficiency and endometrial cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235885/ https://www.ncbi.nlm.nih.gov/pubmed/22175017 http://dx.doi.org/10.4061/2011/256063 |
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