Cargando…
The Role of Oxidative Stress on the Pathogenesis of Graves' Disease
Graves' disease is a most common cause of hyperthyroidism. It is an autoimmune disease, and autoimmune process induces an inflammatory reaction, and reactive oxygen species (ROSs) are among its products. When balance between oxidants and antioxidants is disturbed, in favour of the oxidants it i...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235898/ https://www.ncbi.nlm.nih.gov/pubmed/22175033 http://dx.doi.org/10.1155/2012/302537 |
_version_ | 1782218658089533440 |
---|---|
author | Žarković, Miloš |
author_facet | Žarković, Miloš |
author_sort | Žarković, Miloš |
collection | PubMed |
description | Graves' disease is a most common cause of hyperthyroidism. It is an autoimmune disease, and autoimmune process induces an inflammatory reaction, and reactive oxygen species (ROSs) are among its products. When balance between oxidants and antioxidants is disturbed, in favour of the oxidants it is termed “oxidative stress” (OS). Increased OS characterizes Graves' disease. It seems that the level of OS is increased in subjects with Graves' ophthalmopathy compared to the other subjects with Graves' disease. Among the other factors, OS is involved in proliferation of orbital fibroblasts. Polymorphism of the 8-oxoG DNA N-glycosylase 1 (hOGG1) involved in repair of the oxidative damaged DNA increases in the risk for developing Grave's disease. Treatment with glucocorticoids reduces levels of OS markers. A recent large clinical trial evaluated effect of selenium on mild Graves' ophthalmopathy. Selenium treatment was associated with an improved quality of life and less eye involvement and slowed the progression of Graves' orbitopathy, compared to placebo. |
format | Online Article Text |
id | pubmed-3235898 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32358982011-12-15 The Role of Oxidative Stress on the Pathogenesis of Graves' Disease Žarković, Miloš J Thyroid Res Review Article Graves' disease is a most common cause of hyperthyroidism. It is an autoimmune disease, and autoimmune process induces an inflammatory reaction, and reactive oxygen species (ROSs) are among its products. When balance between oxidants and antioxidants is disturbed, in favour of the oxidants it is termed “oxidative stress” (OS). Increased OS characterizes Graves' disease. It seems that the level of OS is increased in subjects with Graves' ophthalmopathy compared to the other subjects with Graves' disease. Among the other factors, OS is involved in proliferation of orbital fibroblasts. Polymorphism of the 8-oxoG DNA N-glycosylase 1 (hOGG1) involved in repair of the oxidative damaged DNA increases in the risk for developing Grave's disease. Treatment with glucocorticoids reduces levels of OS markers. A recent large clinical trial evaluated effect of selenium on mild Graves' ophthalmopathy. Selenium treatment was associated with an improved quality of life and less eye involvement and slowed the progression of Graves' orbitopathy, compared to placebo. Hindawi Publishing Corporation 2012 2011-12-10 /pmc/articles/PMC3235898/ /pubmed/22175033 http://dx.doi.org/10.1155/2012/302537 Text en Copyright © 2012 Miloš Žarković. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Žarković, Miloš The Role of Oxidative Stress on the Pathogenesis of Graves' Disease |
title | The Role of Oxidative Stress on the Pathogenesis of Graves' Disease |
title_full | The Role of Oxidative Stress on the Pathogenesis of Graves' Disease |
title_fullStr | The Role of Oxidative Stress on the Pathogenesis of Graves' Disease |
title_full_unstemmed | The Role of Oxidative Stress on the Pathogenesis of Graves' Disease |
title_short | The Role of Oxidative Stress on the Pathogenesis of Graves' Disease |
title_sort | role of oxidative stress on the pathogenesis of graves' disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3235898/ https://www.ncbi.nlm.nih.gov/pubmed/22175033 http://dx.doi.org/10.1155/2012/302537 |
work_keys_str_mv | AT zarkovicmilos theroleofoxidativestressonthepathogenesisofgravesdisease AT zarkovicmilos roleofoxidativestressonthepathogenesisofgravesdisease |