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Biomolecular Self-Defense and Futility of High-Specificity Therapeutic Targeting

Robustness has been long recognized to be a distinctive property of living entities. While a reasonably wide consensus has been achieved regarding the conceptual meaning of robustness, the biomolecular mechanisms underlying this systemic property are still open to many unresolved questions. The goal...

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Detalles Bibliográficos
Autor principal: Rosenfeld, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236005/
https://www.ncbi.nlm.nih.gov/pubmed/22272063
http://dx.doi.org/10.4137/GRSB.S8542
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author Rosenfeld, Simon
author_facet Rosenfeld, Simon
author_sort Rosenfeld, Simon
collection PubMed
description Robustness has been long recognized to be a distinctive property of living entities. While a reasonably wide consensus has been achieved regarding the conceptual meaning of robustness, the biomolecular mechanisms underlying this systemic property are still open to many unresolved questions. The goal of this paper is to provide an overview of existing approaches to characterization of robustness in mathematically sound terms. The concept of robustness is discussed in various contexts including network vulnerability, nonlinear dynamic stability, and self-organization. The second goal is to discuss the implications of biological robustness for individual-target therapeutics and possible strategies for outsmarting drug resistance arising from it. Special attention is paid to the concept of swarm intelligence, a well studied mechanism of self-organization in natural, societal and artificial systems. It is hypothesized that swarm intelligence is the key to understanding the emergent property of chemoresistance.
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spelling pubmed-32360052012-01-23 Biomolecular Self-Defense and Futility of High-Specificity Therapeutic Targeting Rosenfeld, Simon Gene Regul Syst Bio Perspective Robustness has been long recognized to be a distinctive property of living entities. While a reasonably wide consensus has been achieved regarding the conceptual meaning of robustness, the biomolecular mechanisms underlying this systemic property are still open to many unresolved questions. The goal of this paper is to provide an overview of existing approaches to characterization of robustness in mathematically sound terms. The concept of robustness is discussed in various contexts including network vulnerability, nonlinear dynamic stability, and self-organization. The second goal is to discuss the implications of biological robustness for individual-target therapeutics and possible strategies for outsmarting drug resistance arising from it. Special attention is paid to the concept of swarm intelligence, a well studied mechanism of self-organization in natural, societal and artificial systems. It is hypothesized that swarm intelligence is the key to understanding the emergent property of chemoresistance. Libertas Academica 2011-11-21 /pmc/articles/PMC3236005/ /pubmed/22272063 http://dx.doi.org/10.4137/GRSB.S8542 Text en © the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited.
spellingShingle Perspective
Rosenfeld, Simon
Biomolecular Self-Defense and Futility of High-Specificity Therapeutic Targeting
title Biomolecular Self-Defense and Futility of High-Specificity Therapeutic Targeting
title_full Biomolecular Self-Defense and Futility of High-Specificity Therapeutic Targeting
title_fullStr Biomolecular Self-Defense and Futility of High-Specificity Therapeutic Targeting
title_full_unstemmed Biomolecular Self-Defense and Futility of High-Specificity Therapeutic Targeting
title_short Biomolecular Self-Defense and Futility of High-Specificity Therapeutic Targeting
title_sort biomolecular self-defense and futility of high-specificity therapeutic targeting
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236005/
https://www.ncbi.nlm.nih.gov/pubmed/22272063
http://dx.doi.org/10.4137/GRSB.S8542
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