Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms

In a previous study, we identified somatic mutations of SF3B1, a gene encoding a core component of RNA splicing machinery, in patients with myelodysplastic syndrome (MDS). Here, we define the clinical significance of these mutations in MDS and myelodysplastic/myeloproliferative neoplasms (MDS/MPN)....

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Detalles Bibliográficos
Autores principales: Malcovati, Luca, Papaemmanuil, Elli, Bowen, David T., Boultwood, Jacqueline, Della Porta, Matteo G., Pascutto, Cristiana, Travaglino, Erica, Groves, Michael J., Godfrey, Anna L., Ambaglio, Ilaria, Gallì, Anna, Da Vià, Matteo C., Conte, Simona, Tauro, Sudhir, Keenan, Norene, Hyslop, Ann, Hinton, Jonathan, Mudie, Laura J., Wainscoat, James S., Futreal, P. Andrew, Stratton, Michael R., Campbell, Peter J., Hellström-Lindberg, Eva, Cazzola, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Hematology 2011
Materias:
Plenary Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236114/
https://www.ncbi.nlm.nih.gov/pubmed/21998214
http://dx.doi.org/10.1182/blood-2011-09-377275

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