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Development of Derivatives of 3, 3′-Diindolylmethane as Potent Leishmania donovani Bi-Subunit Topoisomerase IB Poisons
BACKGROUND: The development of 3, 3′-diindolyl methane (DIM) resistant parasite Leishmania donovani (LdDR50) by adaptation with increasing concentrations of the drug generates random mutations in the large and small subunits of heterodimeric DNA topoisomerase I of Leishmania (LdTOP1LS). Mutation of...
Autores principales: | Roy, Amit, Chowdhury, Sayan, Sengupta, Souvik, Mandal, Madhumita, Jaisankar, Parasuraman, D'Annessa, Ilda, Desideri, Alessandro, Majumder, Hemanta K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236199/ https://www.ncbi.nlm.nih.gov/pubmed/22174820 http://dx.doi.org/10.1371/journal.pone.0028493 |
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