Development of Allele-Specific Therapeutic siRNA in Meesmann Epithelial Corneal Dystrophy

BACKGROUND: Meesmann epithelial corneal dystrophy (MECD) is an inherited eye disorder caused by dominant-negative mutations in either keratins K3 or K12, leading to mechanical fragility of the anterior corneal epithelium, the outermost covering of the eye. Typically, patients suffer from lifelong ir...

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Detalles Bibliográficos
Autores principales: Liao, Haihui, Irvine, Alan D., MacEwen, Caroline J., Weed, Kathryn H., Porter, Louise, Corden, Laura D., Gibson, A. Bethany, Moore, Jonathan E., Smith, Frances J. D., McLean, W. H. Irwin, Moore, C. B. Tara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236202/
https://www.ncbi.nlm.nih.gov/pubmed/22174841
http://dx.doi.org/10.1371/journal.pone.0028582

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