Osteoblastic and Vascular Endothelial Niches, Their Control on Normal Hematopoietic Stem Cells, and Their Consequences on the Development of Leukemia

Stem cell self-renewal is regulated by intrinsic mechanisms and extrinsic signals mediated via specialized microenvironments called “niches.” The best-characterized stem cell is the hematopoietic stem cell (HSC). Self-renewal and differentiation ability of HSC are regulated by two major elements: en...

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Detalles Bibliográficos
Autores principales: Guerrouahen, Bella S., Al-Hijji, Ibrahim, Tabrizi, Arash Rafii
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236318/
https://www.ncbi.nlm.nih.gov/pubmed/22190963
http://dx.doi.org/10.4061/2011/375857

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