Identification of germline alterations of the mad homology 2 domain of SMAD3 and SMAD4 from the Ontario site of the breast cancer family registry (CFR)

INTRODUCTION: A common feature of neoplastic cells is that mutations in SMADs can contribute to the loss of sensitivity to the anti-tumor effects of transforming growth factor-β (TGF-β). However, germline mutation analysis of SMAD3 and SMAD4, the principle substrates of the TGF-β signaling pathway,...

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Detalles Bibliográficos
Autores principales: Tram, Eric, Ibrahim-zada, Irada, Briollais, Laurent, Knight, Julia A, Andrulis, Irene L, Ozcelik, Hilmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236341/
https://www.ncbi.nlm.nih.gov/pubmed/21835029
http://dx.doi.org/10.1186/bcr2926

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