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Spleen as a Site for Hematopoiesis of a Distinct Antigen Presenting Cell Type
While spleen and other secondary tissue sites contribute to hematopoiesis, the nature of cells produced and the environment under which this happens are not fully defined. Evidence is reviewed here for hematopoiesis occurring in the spleen microenvironment leading to the production of tissue-specifi...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236354/ https://www.ncbi.nlm.nih.gov/pubmed/22190965 http://dx.doi.org/10.4061/2011/954275 |
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author | O'Neill, Helen C. Griffiths, Kristin L. Periasamy, Pravin Hinton, Rebecca A. Hey, Ying-Ying Petvises, Sawang Tan, Jonathan K. H. |
author_facet | O'Neill, Helen C. Griffiths, Kristin L. Periasamy, Pravin Hinton, Rebecca A. Hey, Ying-Ying Petvises, Sawang Tan, Jonathan K. H. |
author_sort | O'Neill, Helen C. |
collection | PubMed |
description | While spleen and other secondary tissue sites contribute to hematopoiesis, the nature of cells produced and the environment under which this happens are not fully defined. Evidence is reviewed here for hematopoiesis occurring in the spleen microenvironment leading to the production of tissue-specific antigen presenting cells. The novel dendritic-like cell identified in spleen is phenotypically and functionally distinct from other described antigen presenting cells. In order to identify these cells as distinct, it has been necessary to show that their lineage origin and progenitors differ from that of other known dendritic and myeloid cell types. The spleen therefore represents a distinct microenvironment for hematopoiesis of a novel myeloid cell arising from self-renewing hematopoietic stem cells (HSC) or progenitors endogenous to spleen. |
format | Online Article Text |
id | pubmed-3236354 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-32363542011-12-21 Spleen as a Site for Hematopoiesis of a Distinct Antigen Presenting Cell Type O'Neill, Helen C. Griffiths, Kristin L. Periasamy, Pravin Hinton, Rebecca A. Hey, Ying-Ying Petvises, Sawang Tan, Jonathan K. H. Stem Cells Int Review Article While spleen and other secondary tissue sites contribute to hematopoiesis, the nature of cells produced and the environment under which this happens are not fully defined. Evidence is reviewed here for hematopoiesis occurring in the spleen microenvironment leading to the production of tissue-specific antigen presenting cells. The novel dendritic-like cell identified in spleen is phenotypically and functionally distinct from other described antigen presenting cells. In order to identify these cells as distinct, it has been necessary to show that their lineage origin and progenitors differ from that of other known dendritic and myeloid cell types. The spleen therefore represents a distinct microenvironment for hematopoiesis of a novel myeloid cell arising from self-renewing hematopoietic stem cells (HSC) or progenitors endogenous to spleen. SAGE-Hindawi Access to Research 2011 2011-11-15 /pmc/articles/PMC3236354/ /pubmed/22190965 http://dx.doi.org/10.4061/2011/954275 Text en Copyright © 2011 Helen C. O'Neill et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article O'Neill, Helen C. Griffiths, Kristin L. Periasamy, Pravin Hinton, Rebecca A. Hey, Ying-Ying Petvises, Sawang Tan, Jonathan K. H. Spleen as a Site for Hematopoiesis of a Distinct Antigen Presenting Cell Type |
title | Spleen as a Site for Hematopoiesis of a Distinct Antigen Presenting Cell Type |
title_full | Spleen as a Site for Hematopoiesis of a Distinct Antigen Presenting Cell Type |
title_fullStr | Spleen as a Site for Hematopoiesis of a Distinct Antigen Presenting Cell Type |
title_full_unstemmed | Spleen as a Site for Hematopoiesis of a Distinct Antigen Presenting Cell Type |
title_short | Spleen as a Site for Hematopoiesis of a Distinct Antigen Presenting Cell Type |
title_sort | spleen as a site for hematopoiesis of a distinct antigen presenting cell type |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236354/ https://www.ncbi.nlm.nih.gov/pubmed/22190965 http://dx.doi.org/10.4061/2011/954275 |
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