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Spleen as a Site for Hematopoiesis of a Distinct Antigen Presenting Cell Type

While spleen and other secondary tissue sites contribute to hematopoiesis, the nature of cells produced and the environment under which this happens are not fully defined. Evidence is reviewed here for hematopoiesis occurring in the spleen microenvironment leading to the production of tissue-specifi...

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Autores principales: O'Neill, Helen C., Griffiths, Kristin L., Periasamy, Pravin, Hinton, Rebecca A., Hey, Ying-Ying, Petvises, Sawang, Tan, Jonathan K. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236354/
https://www.ncbi.nlm.nih.gov/pubmed/22190965
http://dx.doi.org/10.4061/2011/954275
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author O'Neill, Helen C.
Griffiths, Kristin L.
Periasamy, Pravin
Hinton, Rebecca A.
Hey, Ying-Ying
Petvises, Sawang
Tan, Jonathan K. H.
author_facet O'Neill, Helen C.
Griffiths, Kristin L.
Periasamy, Pravin
Hinton, Rebecca A.
Hey, Ying-Ying
Petvises, Sawang
Tan, Jonathan K. H.
author_sort O'Neill, Helen C.
collection PubMed
description While spleen and other secondary tissue sites contribute to hematopoiesis, the nature of cells produced and the environment under which this happens are not fully defined. Evidence is reviewed here for hematopoiesis occurring in the spleen microenvironment leading to the production of tissue-specific antigen presenting cells. The novel dendritic-like cell identified in spleen is phenotypically and functionally distinct from other described antigen presenting cells. In order to identify these cells as distinct, it has been necessary to show that their lineage origin and progenitors differ from that of other known dendritic and myeloid cell types. The spleen therefore represents a distinct microenvironment for hematopoiesis of a novel myeloid cell arising from self-renewing hematopoietic stem cells (HSC) or progenitors endogenous to spleen.
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spelling pubmed-32363542011-12-21 Spleen as a Site for Hematopoiesis of a Distinct Antigen Presenting Cell Type O'Neill, Helen C. Griffiths, Kristin L. Periasamy, Pravin Hinton, Rebecca A. Hey, Ying-Ying Petvises, Sawang Tan, Jonathan K. H. Stem Cells Int Review Article While spleen and other secondary tissue sites contribute to hematopoiesis, the nature of cells produced and the environment under which this happens are not fully defined. Evidence is reviewed here for hematopoiesis occurring in the spleen microenvironment leading to the production of tissue-specific antigen presenting cells. The novel dendritic-like cell identified in spleen is phenotypically and functionally distinct from other described antigen presenting cells. In order to identify these cells as distinct, it has been necessary to show that their lineage origin and progenitors differ from that of other known dendritic and myeloid cell types. The spleen therefore represents a distinct microenvironment for hematopoiesis of a novel myeloid cell arising from self-renewing hematopoietic stem cells (HSC) or progenitors endogenous to spleen. SAGE-Hindawi Access to Research 2011 2011-11-15 /pmc/articles/PMC3236354/ /pubmed/22190965 http://dx.doi.org/10.4061/2011/954275 Text en Copyright © 2011 Helen C. O'Neill et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
O'Neill, Helen C.
Griffiths, Kristin L.
Periasamy, Pravin
Hinton, Rebecca A.
Hey, Ying-Ying
Petvises, Sawang
Tan, Jonathan K. H.
Spleen as a Site for Hematopoiesis of a Distinct Antigen Presenting Cell Type
title Spleen as a Site for Hematopoiesis of a Distinct Antigen Presenting Cell Type
title_full Spleen as a Site for Hematopoiesis of a Distinct Antigen Presenting Cell Type
title_fullStr Spleen as a Site for Hematopoiesis of a Distinct Antigen Presenting Cell Type
title_full_unstemmed Spleen as a Site for Hematopoiesis of a Distinct Antigen Presenting Cell Type
title_short Spleen as a Site for Hematopoiesis of a Distinct Antigen Presenting Cell Type
title_sort spleen as a site for hematopoiesis of a distinct antigen presenting cell type
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236354/
https://www.ncbi.nlm.nih.gov/pubmed/22190965
http://dx.doi.org/10.4061/2011/954275
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