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Skeletal Effects of the Saturated 3-Thia Fatty Acid Tetradecylthioacetic Acid in Rats

This study explores the skeletal effects of the peroxisome proliferator activated receptor (PPAR)pan agonist tetradecylthioacetic acid (TTA). Rats, without (Study I) and with ovariectomy (OVX) or sham operation (Study II), were given TTA or vehicle daily for 4 months. Bone markers in plasma, whole b...

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Autores principales: Stunes, Astrid Kamilla, Westbroek, Irene, Fossmark, Reidar, Berge, Rolf Kristian, Reseland, Janne Elin, Syversen, Unni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236357/
https://www.ncbi.nlm.nih.gov/pubmed/22190907
http://dx.doi.org/10.1155/2011/436358
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author Stunes, Astrid Kamilla
Westbroek, Irene
Fossmark, Reidar
Berge, Rolf Kristian
Reseland, Janne Elin
Syversen, Unni
author_facet Stunes, Astrid Kamilla
Westbroek, Irene
Fossmark, Reidar
Berge, Rolf Kristian
Reseland, Janne Elin
Syversen, Unni
author_sort Stunes, Astrid Kamilla
collection PubMed
description This study explores the skeletal effects of the peroxisome proliferator activated receptor (PPAR)pan agonist tetradecylthioacetic acid (TTA). Rats, without (Study I) and with ovariectomy (OVX) or sham operation (Study II), were given TTA or vehicle daily for 4 months. Bone markers in plasma, whole body and femoral bone mineral density and content (BMD and BMC), and body composition were examined. Histomorphometric and biomechanical analyses (Study I) and biomechanical and μCT analyses (Study II) of the femur were performed. Normal rats fed TTA had higher femoral BMD and increased total and cortical area in femur compared to controls. The ovariectomized groups had decreased BMD and impaired microarchitecture parameters compared to SHAM. However, the TTA OVX group maintained femoral BMC, trabecular thickness in the femoral head, and cortical volume in the femoral metaphysis as SHAM. TTA might increase BMD and exert a light preventive effect on estrogen-related bone loss in rats.
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spelling pubmed-32363572011-12-21 Skeletal Effects of the Saturated 3-Thia Fatty Acid Tetradecylthioacetic Acid in Rats Stunes, Astrid Kamilla Westbroek, Irene Fossmark, Reidar Berge, Rolf Kristian Reseland, Janne Elin Syversen, Unni PPAR Res Research Article This study explores the skeletal effects of the peroxisome proliferator activated receptor (PPAR)pan agonist tetradecylthioacetic acid (TTA). Rats, without (Study I) and with ovariectomy (OVX) or sham operation (Study II), were given TTA or vehicle daily for 4 months. Bone markers in plasma, whole body and femoral bone mineral density and content (BMD and BMC), and body composition were examined. Histomorphometric and biomechanical analyses (Study I) and biomechanical and μCT analyses (Study II) of the femur were performed. Normal rats fed TTA had higher femoral BMD and increased total and cortical area in femur compared to controls. The ovariectomized groups had decreased BMD and impaired microarchitecture parameters compared to SHAM. However, the TTA OVX group maintained femoral BMC, trabecular thickness in the femoral head, and cortical volume in the femoral metaphysis as SHAM. TTA might increase BMD and exert a light preventive effect on estrogen-related bone loss in rats. Hindawi Publishing Corporation 2011 2011-12-05 /pmc/articles/PMC3236357/ /pubmed/22190907 http://dx.doi.org/10.1155/2011/436358 Text en Copyright © 2011 Astrid Kamilla Stunes et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Stunes, Astrid Kamilla
Westbroek, Irene
Fossmark, Reidar
Berge, Rolf Kristian
Reseland, Janne Elin
Syversen, Unni
Skeletal Effects of the Saturated 3-Thia Fatty Acid Tetradecylthioacetic Acid in Rats
title Skeletal Effects of the Saturated 3-Thia Fatty Acid Tetradecylthioacetic Acid in Rats
title_full Skeletal Effects of the Saturated 3-Thia Fatty Acid Tetradecylthioacetic Acid in Rats
title_fullStr Skeletal Effects of the Saturated 3-Thia Fatty Acid Tetradecylthioacetic Acid in Rats
title_full_unstemmed Skeletal Effects of the Saturated 3-Thia Fatty Acid Tetradecylthioacetic Acid in Rats
title_short Skeletal Effects of the Saturated 3-Thia Fatty Acid Tetradecylthioacetic Acid in Rats
title_sort skeletal effects of the saturated 3-thia fatty acid tetradecylthioacetic acid in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236357/
https://www.ncbi.nlm.nih.gov/pubmed/22190907
http://dx.doi.org/10.1155/2011/436358
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