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Axial Skeletal Location Predicts Poor Outcome in Ewing's Sarcoma: A Single Institution Experience

Introduction. Ewing's sarcomas (EWSs) of bone and soft tissue are neuroectodermal tumors that affect both axial and appendicular locations. We hypothesized that axial location predicted poor outcome in EWS patients. Materials and Methods. Sixty-seven patients (57 with bone EWS and 10 with soft...

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Autores principales: Weiss, Kurt R., Biau, David J., Bhumbra, Rej, Griffin, Anthony M., Blackstein, Martin E., Chung, Peter, Catton, Charles, O'Sullivan, Brian, Ferguson, Peter C., Wunder, Jay S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236362/
https://www.ncbi.nlm.nih.gov/pubmed/22190863
http://dx.doi.org/10.1155/2011/395180
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author Weiss, Kurt R.
Biau, David J.
Bhumbra, Rej
Griffin, Anthony M.
Blackstein, Martin E.
Chung, Peter
Catton, Charles
O'Sullivan, Brian
Ferguson, Peter C.
Wunder, Jay S.
author_facet Weiss, Kurt R.
Biau, David J.
Bhumbra, Rej
Griffin, Anthony M.
Blackstein, Martin E.
Chung, Peter
Catton, Charles
O'Sullivan, Brian
Ferguson, Peter C.
Wunder, Jay S.
author_sort Weiss, Kurt R.
collection PubMed
description Introduction. Ewing's sarcomas (EWSs) of bone and soft tissue are neuroectodermal tumors that affect both axial and appendicular locations. We hypothesized that axial location predicted poor outcome in EWS patients. Materials and Methods. Sixty-seven patients (57 with bone EWS and 10 with soft tissue EWS) were identified from our database. Thirty-four (51%) had axial EWS and 33 (49%) had appendicular EWS. Statistical analyses identified predictors of poor outcome. Results and Discussion. Axial location, large size, metastases at presentation, lack of definitive treatment, and positive surgical margins all correlated with poor outcome in univariate analysis. In multivariate analysis, axial location still predicted poor outcome when adjusted for pretreatment variables. Axial location was not statistically predictive of poor outcome when adjusted for treatment variables. Conclusions. Anatomic location has a negative effect on outcome in EWS that cannot be completely explained by pretreatment or treatment factors. Additional studies are required to determine if there is a biologic difference between axial and appendicular EWS.
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spelling pubmed-32363622011-12-21 Axial Skeletal Location Predicts Poor Outcome in Ewing's Sarcoma: A Single Institution Experience Weiss, Kurt R. Biau, David J. Bhumbra, Rej Griffin, Anthony M. Blackstein, Martin E. Chung, Peter Catton, Charles O'Sullivan, Brian Ferguson, Peter C. Wunder, Jay S. Sarcoma Clinical Study Introduction. Ewing's sarcomas (EWSs) of bone and soft tissue are neuroectodermal tumors that affect both axial and appendicular locations. We hypothesized that axial location predicted poor outcome in EWS patients. Materials and Methods. Sixty-seven patients (57 with bone EWS and 10 with soft tissue EWS) were identified from our database. Thirty-four (51%) had axial EWS and 33 (49%) had appendicular EWS. Statistical analyses identified predictors of poor outcome. Results and Discussion. Axial location, large size, metastases at presentation, lack of definitive treatment, and positive surgical margins all correlated with poor outcome in univariate analysis. In multivariate analysis, axial location still predicted poor outcome when adjusted for pretreatment variables. Axial location was not statistically predictive of poor outcome when adjusted for treatment variables. Conclusions. Anatomic location has a negative effect on outcome in EWS that cannot be completely explained by pretreatment or treatment factors. Additional studies are required to determine if there is a biologic difference between axial and appendicular EWS. Hindawi Publishing Corporation 2011 2011-11-24 /pmc/articles/PMC3236362/ /pubmed/22190863 http://dx.doi.org/10.1155/2011/395180 Text en Copyright © 2011 Kurt R. Weiss et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Weiss, Kurt R.
Biau, David J.
Bhumbra, Rej
Griffin, Anthony M.
Blackstein, Martin E.
Chung, Peter
Catton, Charles
O'Sullivan, Brian
Ferguson, Peter C.
Wunder, Jay S.
Axial Skeletal Location Predicts Poor Outcome in Ewing's Sarcoma: A Single Institution Experience
title Axial Skeletal Location Predicts Poor Outcome in Ewing's Sarcoma: A Single Institution Experience
title_full Axial Skeletal Location Predicts Poor Outcome in Ewing's Sarcoma: A Single Institution Experience
title_fullStr Axial Skeletal Location Predicts Poor Outcome in Ewing's Sarcoma: A Single Institution Experience
title_full_unstemmed Axial Skeletal Location Predicts Poor Outcome in Ewing's Sarcoma: A Single Institution Experience
title_short Axial Skeletal Location Predicts Poor Outcome in Ewing's Sarcoma: A Single Institution Experience
title_sort axial skeletal location predicts poor outcome in ewing's sarcoma: a single institution experience
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236362/
https://www.ncbi.nlm.nih.gov/pubmed/22190863
http://dx.doi.org/10.1155/2011/395180
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