Iron Inhibits Respiratory Burst of Peritoneal Phagocytes In Vitro

Objective. This study examines the effects of iron ions Fe(3+) on the respiratory burst of phagocytes isolated from peritoneal effluents of continuous ambulatory peritoneal dialysis (CAPD) patients, as an in vitro model of iron overload in end-stage renal disease (ESRD). Material and Methods. Respir...

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Autores principales: Gotfryd, Kamil, Jurek, Aleksandra, Kubit, Piotr, Klein, Andrzej, Turyna, Bohdan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236377/
https://www.ncbi.nlm.nih.gov/pubmed/22203913
http://dx.doi.org/10.5402/2011/605436
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author Gotfryd, Kamil
Jurek, Aleksandra
Kubit, Piotr
Klein, Andrzej
Turyna, Bohdan
author_facet Gotfryd, Kamil
Jurek, Aleksandra
Kubit, Piotr
Klein, Andrzej
Turyna, Bohdan
author_sort Gotfryd, Kamil
collection PubMed
description Objective. This study examines the effects of iron ions Fe(3+) on the respiratory burst of phagocytes isolated from peritoneal effluents of continuous ambulatory peritoneal dialysis (CAPD) patients, as an in vitro model of iron overload in end-stage renal disease (ESRD). Material and Methods. Respiratory burst of peritoneal phagocytes was measured by chemiluminescence method. Results. At the highest used concentration of iron ions Fe(3+) (100 μM), free radicals production by peritoneal phagocytes was reduced by 90% compared to control. Conclusions. Iron overload may increase the risk of infectious complications in ESRD patients.
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spelling pubmed-32363772011-12-27 Iron Inhibits Respiratory Burst of Peritoneal Phagocytes In Vitro Gotfryd, Kamil Jurek, Aleksandra Kubit, Piotr Klein, Andrzej Turyna, Bohdan ISRN Urol Research Article Objective. This study examines the effects of iron ions Fe(3+) on the respiratory burst of phagocytes isolated from peritoneal effluents of continuous ambulatory peritoneal dialysis (CAPD) patients, as an in vitro model of iron overload in end-stage renal disease (ESRD). Material and Methods. Respiratory burst of peritoneal phagocytes was measured by chemiluminescence method. Results. At the highest used concentration of iron ions Fe(3+) (100 μM), free radicals production by peritoneal phagocytes was reduced by 90% compared to control. Conclusions. Iron overload may increase the risk of infectious complications in ESRD patients. International Scholarly Research Network 2011 2011-12-08 /pmc/articles/PMC3236377/ /pubmed/22203913 http://dx.doi.org/10.5402/2011/605436 Text en Copyright © 2011 Kamil Gotfryd et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Gotfryd, Kamil
Jurek, Aleksandra
Kubit, Piotr
Klein, Andrzej
Turyna, Bohdan
Iron Inhibits Respiratory Burst of Peritoneal Phagocytes In Vitro
title Iron Inhibits Respiratory Burst of Peritoneal Phagocytes In Vitro
title_full Iron Inhibits Respiratory Burst of Peritoneal Phagocytes In Vitro
title_fullStr Iron Inhibits Respiratory Burst of Peritoneal Phagocytes In Vitro
title_full_unstemmed Iron Inhibits Respiratory Burst of Peritoneal Phagocytes In Vitro
title_short Iron Inhibits Respiratory Burst of Peritoneal Phagocytes In Vitro
title_sort iron inhibits respiratory burst of peritoneal phagocytes in vitro
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236377/
https://www.ncbi.nlm.nih.gov/pubmed/22203913
http://dx.doi.org/10.5402/2011/605436
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