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The Importance of Being Profiled: Improving Drug Candidate Safety and Efficacy Using Ion Channel Profiling
Profiling of putative lead compounds against a representative panel of relevant enzymes, receptors, ion channels, and transporters is a pragmatic approach to establish a preliminary view of potential issues that might later hamper development. An early idea of which off-target activities must be min...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Research Foundation
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236397/ https://www.ncbi.nlm.nih.gov/pubmed/22171219 http://dx.doi.org/10.3389/fphar.2011.00078 |