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Chitin, Chitinase Responses, and Invasive Fungal Infections

The human immune system is capable of recognizing and degrading chitin, an important cell wall component of pathogenic fungi. In the context of host-immune responses to fungal infections, herein we review the particular contributions and interplay of fungus and chitin recognition, and chitin-degradi...

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Autores principales: Vega, Karina, Kalkum, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236456/
https://www.ncbi.nlm.nih.gov/pubmed/22187561
http://dx.doi.org/10.1155/2012/920459
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author Vega, Karina
Kalkum, Markus
author_facet Vega, Karina
Kalkum, Markus
author_sort Vega, Karina
collection PubMed
description The human immune system is capable of recognizing and degrading chitin, an important cell wall component of pathogenic fungi. In the context of host-immune responses to fungal infections, herein we review the particular contributions and interplay of fungus and chitin recognition, and chitin-degrading enzymes, known as chitinases. The mechanisms of host chitinase responses may have implications for diagnostic assays as well as novel therapeutic approaches for patients that are at risk of contracting fatal fungal infections.
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spelling pubmed-32364562011-12-20 Chitin, Chitinase Responses, and Invasive Fungal Infections Vega, Karina Kalkum, Markus Int J Microbiol Review Article The human immune system is capable of recognizing and degrading chitin, an important cell wall component of pathogenic fungi. In the context of host-immune responses to fungal infections, herein we review the particular contributions and interplay of fungus and chitin recognition, and chitin-degrading enzymes, known as chitinases. The mechanisms of host chitinase responses may have implications for diagnostic assays as well as novel therapeutic approaches for patients that are at risk of contracting fatal fungal infections. Hindawi Publishing Corporation 2012 2011-12-11 /pmc/articles/PMC3236456/ /pubmed/22187561 http://dx.doi.org/10.1155/2012/920459 Text en Copyright © 2012 K. Vega and M. Kalkum. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Vega, Karina
Kalkum, Markus
Chitin, Chitinase Responses, and Invasive Fungal Infections
title Chitin, Chitinase Responses, and Invasive Fungal Infections
title_full Chitin, Chitinase Responses, and Invasive Fungal Infections
title_fullStr Chitin, Chitinase Responses, and Invasive Fungal Infections
title_full_unstemmed Chitin, Chitinase Responses, and Invasive Fungal Infections
title_short Chitin, Chitinase Responses, and Invasive Fungal Infections
title_sort chitin, chitinase responses, and invasive fungal infections
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236456/
https://www.ncbi.nlm.nih.gov/pubmed/22187561
http://dx.doi.org/10.1155/2012/920459
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