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Antifungal Resistance and New Strategies to Control Fungal Infections

Despite improvement of antifungal therapies over the last 30 years, the phenomenon of antifungal resistance is still of major concern in clinical practice. In the last 10 years the molecular mechanisms underlying this phenomenon were extensively unraveled. In this paper, after a brief overview of cu...

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Autores principales: Vandeputte, Patrick, Ferrari, Selene, Coste, Alix T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236459/
https://www.ncbi.nlm.nih.gov/pubmed/22187560
http://dx.doi.org/10.1155/2012/713687
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author Vandeputte, Patrick
Ferrari, Selene
Coste, Alix T.
author_facet Vandeputte, Patrick
Ferrari, Selene
Coste, Alix T.
author_sort Vandeputte, Patrick
collection PubMed
description Despite improvement of antifungal therapies over the last 30 years, the phenomenon of antifungal resistance is still of major concern in clinical practice. In the last 10 years the molecular mechanisms underlying this phenomenon were extensively unraveled. In this paper, after a brief overview of currently available antifungals, molecular mechanisms of antifungal resistance will be detailed. It appears that major mechanisms of resistance are essential due to the deregulation of antifungal resistance effector genes. This deregulation is a consequence of point mutations occurring in transcriptional regulators of these effector genes. Resistance can also follow the emergence of point mutations directly in the genes coding antifungal targets. In addition we further describe new strategies currently undertaken to discover alternative therapy targets and antifungals. Identification of new antifungals is essentially achieved by the screening of natural or synthetic chemical compound collections. Discovery of new putative antifungal targets is performed through genome-wide approaches for a better understanding of the human pathogenic fungi biology.
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spelling pubmed-32364592011-12-20 Antifungal Resistance and New Strategies to Control Fungal Infections Vandeputte, Patrick Ferrari, Selene Coste, Alix T. Int J Microbiol Review Article Despite improvement of antifungal therapies over the last 30 years, the phenomenon of antifungal resistance is still of major concern in clinical practice. In the last 10 years the molecular mechanisms underlying this phenomenon were extensively unraveled. In this paper, after a brief overview of currently available antifungals, molecular mechanisms of antifungal resistance will be detailed. It appears that major mechanisms of resistance are essential due to the deregulation of antifungal resistance effector genes. This deregulation is a consequence of point mutations occurring in transcriptional regulators of these effector genes. Resistance can also follow the emergence of point mutations directly in the genes coding antifungal targets. In addition we further describe new strategies currently undertaken to discover alternative therapy targets and antifungals. Identification of new antifungals is essentially achieved by the screening of natural or synthetic chemical compound collections. Discovery of new putative antifungal targets is performed through genome-wide approaches for a better understanding of the human pathogenic fungi biology. Hindawi Publishing Corporation 2012 2011-12-01 /pmc/articles/PMC3236459/ /pubmed/22187560 http://dx.doi.org/10.1155/2012/713687 Text en Copyright © 2012 Patrick Vandeputte et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Vandeputte, Patrick
Ferrari, Selene
Coste, Alix T.
Antifungal Resistance and New Strategies to Control Fungal Infections
title Antifungal Resistance and New Strategies to Control Fungal Infections
title_full Antifungal Resistance and New Strategies to Control Fungal Infections
title_fullStr Antifungal Resistance and New Strategies to Control Fungal Infections
title_full_unstemmed Antifungal Resistance and New Strategies to Control Fungal Infections
title_short Antifungal Resistance and New Strategies to Control Fungal Infections
title_sort antifungal resistance and new strategies to control fungal infections
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236459/
https://www.ncbi.nlm.nih.gov/pubmed/22187560
http://dx.doi.org/10.1155/2012/713687
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