Dynamics of Parasite Clearance in Cutaneous Leishmaniasis Patients Treated with Miltefosine

Parasite loads were quantified in repeated skin biopsies from lesions of 2 patients with Old-World cutaneous leishmaniasis (CL) caused by Leishmania major and L. infantum during and after treatment with miltefosine. Miltefosine induced a rapid therapeutic effect on both infections with an initial de...

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Autores principales: Dorlo, Thomas P. C., van Thiel, Pieter P. A. M., Schoone, Gerard J., Stienstra, Ymkje, van Vugt, Michèle, Beijnen, Jos H., de Vries, Peter J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236732/
https://www.ncbi.nlm.nih.gov/pubmed/22180803
http://dx.doi.org/10.1371/journal.pntd.0001436
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author Dorlo, Thomas P. C.
van Thiel, Pieter P. A. M.
Schoone, Gerard J.
Stienstra, Ymkje
van Vugt, Michèle
Beijnen, Jos H.
de Vries, Peter J.
author_facet Dorlo, Thomas P. C.
van Thiel, Pieter P. A. M.
Schoone, Gerard J.
Stienstra, Ymkje
van Vugt, Michèle
Beijnen, Jos H.
de Vries, Peter J.
author_sort Dorlo, Thomas P. C.
collection PubMed
description Parasite loads were quantified in repeated skin biopsies from lesions of 2 patients with Old-World cutaneous leishmaniasis (CL) caused by Leishmania major and L. infantum during and after treatment with miltefosine. Miltefosine induced a rapid therapeutic effect on both infections with an initial decline of parasites of ∼1 log/week for the L. major infection. These observations illustrate the usability of quantifying parasite loads in skin lesions as a pharmacodynamic measure and quantitative descriptor of drug effect for CL supporting clinical assessment.
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spelling pubmed-32367322011-12-16 Dynamics of Parasite Clearance in Cutaneous Leishmaniasis Patients Treated with Miltefosine Dorlo, Thomas P. C. van Thiel, Pieter P. A. M. Schoone, Gerard J. Stienstra, Ymkje van Vugt, Michèle Beijnen, Jos H. de Vries, Peter J. PLoS Negl Trop Dis Research Article Parasite loads were quantified in repeated skin biopsies from lesions of 2 patients with Old-World cutaneous leishmaniasis (CL) caused by Leishmania major and L. infantum during and after treatment with miltefosine. Miltefosine induced a rapid therapeutic effect on both infections with an initial decline of parasites of ∼1 log/week for the L. major infection. These observations illustrate the usability of quantifying parasite loads in skin lesions as a pharmacodynamic measure and quantitative descriptor of drug effect for CL supporting clinical assessment. Public Library of Science 2011-12-13 /pmc/articles/PMC3236732/ /pubmed/22180803 http://dx.doi.org/10.1371/journal.pntd.0001436 Text en Dorlo et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Dorlo, Thomas P. C.
van Thiel, Pieter P. A. M.
Schoone, Gerard J.
Stienstra, Ymkje
van Vugt, Michèle
Beijnen, Jos H.
de Vries, Peter J.
Dynamics of Parasite Clearance in Cutaneous Leishmaniasis Patients Treated with Miltefosine
title Dynamics of Parasite Clearance in Cutaneous Leishmaniasis Patients Treated with Miltefosine
title_full Dynamics of Parasite Clearance in Cutaneous Leishmaniasis Patients Treated with Miltefosine
title_fullStr Dynamics of Parasite Clearance in Cutaneous Leishmaniasis Patients Treated with Miltefosine
title_full_unstemmed Dynamics of Parasite Clearance in Cutaneous Leishmaniasis Patients Treated with Miltefosine
title_short Dynamics of Parasite Clearance in Cutaneous Leishmaniasis Patients Treated with Miltefosine
title_sort dynamics of parasite clearance in cutaneous leishmaniasis patients treated with miltefosine
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3236732/
https://www.ncbi.nlm.nih.gov/pubmed/22180803
http://dx.doi.org/10.1371/journal.pntd.0001436
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