Experimental Limitations Using Reprogrammed Cells for Hematopoietic Differentiation

We review here our experiences with the in vitro reprogramming of somatic cells to induced pluripotent stem cells (iPSC) and subsequent in vitro development of hematopoietic cells from these iPSC and from embryonic stem cells (ESC). While, in principle, the in vitro reprogramming and subsequent diff...

Descripción completa

Detalles Bibliográficos
Autores principales: Seiler, Katharina, Tsuneto, Motokazu, Melchers, Fritz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237023/
https://www.ncbi.nlm.nih.gov/pubmed/22187531
http://dx.doi.org/10.1155/2011/895086
_version_ 1782218832557899776
author Seiler, Katharina
Tsuneto, Motokazu
Melchers, Fritz
author_facet Seiler, Katharina
Tsuneto, Motokazu
Melchers, Fritz
author_sort Seiler, Katharina
collection PubMed
description We review here our experiences with the in vitro reprogramming of somatic cells to induced pluripotent stem cells (iPSC) and subsequent in vitro development of hematopoietic cells from these iPSC and from embryonic stem cells (ESC). While, in principle, the in vitro reprogramming and subsequent differentiation can generate hematopoietic cell from any somatic cells, it is evident that many of the steps in this process need to be significantly improved before it can be applied to human cells and used in clinical settings of hematopoietic stem cell (HSC) transplantations.
format Online
Article
Text
id pubmed-3237023
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-32370232011-12-20 Experimental Limitations Using Reprogrammed Cells for Hematopoietic Differentiation Seiler, Katharina Tsuneto, Motokazu Melchers, Fritz J Biomed Biotechnol Review Article We review here our experiences with the in vitro reprogramming of somatic cells to induced pluripotent stem cells (iPSC) and subsequent in vitro development of hematopoietic cells from these iPSC and from embryonic stem cells (ESC). While, in principle, the in vitro reprogramming and subsequent differentiation can generate hematopoietic cell from any somatic cells, it is evident that many of the steps in this process need to be significantly improved before it can be applied to human cells and used in clinical settings of hematopoietic stem cell (HSC) transplantations. Hindawi Publishing Corporation 2011 2011-11-30 /pmc/articles/PMC3237023/ /pubmed/22187531 http://dx.doi.org/10.1155/2011/895086 Text en Copyright © 2011 Katharina Seiler et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Seiler, Katharina
Tsuneto, Motokazu
Melchers, Fritz
Experimental Limitations Using Reprogrammed Cells for Hematopoietic Differentiation
title Experimental Limitations Using Reprogrammed Cells for Hematopoietic Differentiation
title_full Experimental Limitations Using Reprogrammed Cells for Hematopoietic Differentiation
title_fullStr Experimental Limitations Using Reprogrammed Cells for Hematopoietic Differentiation
title_full_unstemmed Experimental Limitations Using Reprogrammed Cells for Hematopoietic Differentiation
title_short Experimental Limitations Using Reprogrammed Cells for Hematopoietic Differentiation
title_sort experimental limitations using reprogrammed cells for hematopoietic differentiation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237023/
https://www.ncbi.nlm.nih.gov/pubmed/22187531
http://dx.doi.org/10.1155/2011/895086
work_keys_str_mv AT seilerkatharina experimentallimitationsusingreprogrammedcellsforhematopoieticdifferentiation
AT tsunetomotokazu experimentallimitationsusingreprogrammedcellsforhematopoieticdifferentiation
AT melchersfritz experimentallimitationsusingreprogrammedcellsforhematopoieticdifferentiation

Ejemplares similares