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Primary Squamous Cell Carcinoma of the Liver: An Uncommon Finding in Contrast-Enhanced Ultrasonography Imaging
Primary squamous cell carcinoma (SCC) of the liver is rare tumor with an unfavorable prognosis. We report a case of advanced primary SCC of the liver arising adjacent to a nonparasitic liver cyst, invading into the right diaphragm and the right lung tissue. Contrast-enhanced ultrasonography (CE-US)...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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S. Karger AG
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237109/ https://www.ncbi.nlm.nih.gov/pubmed/22171214 http://dx.doi.org/10.1159/000334425 |
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author | Iimuro, Yuji Asano, Yasukane Suzumura, Kazuhiro Yada, Akito Hirano, Tadamichi Iijima, Hiroko Nishiguchi, Shuhei Hirota, Seiichi Fujimoto, Jiro |
author_facet | Iimuro, Yuji Asano, Yasukane Suzumura, Kazuhiro Yada, Akito Hirano, Tadamichi Iijima, Hiroko Nishiguchi, Shuhei Hirota, Seiichi Fujimoto, Jiro |
author_sort | Iimuro, Yuji |
collection | PubMed |
description | Primary squamous cell carcinoma (SCC) of the liver is rare tumor with an unfavorable prognosis. We report a case of advanced primary SCC of the liver arising adjacent to a nonparasitic liver cyst, invading into the right diaphragm and the right lung tissue. Contrast-enhanced ultrasonography (CE-US) demonstrated unique enhancement in the late vascular phase, which was incompatible with those observed in hepatocellular carcinoma, cholangiocellular carcinoma, or metastatic adenocarcinoma. The patient underwent surgical resection of the tumor followed by systemic chemotherapy with 5-fluorouracil (5-FU) and cisplatin (CDDP), while radiation chemotherapy was not applied because of relatively poor performance status. Although postoperative image analysis revealed no recurrence 4 months later, the patient died 13 months after the operation from recurrence. Immunohistological analysis of the resected specimen revealed that this SCC contained many capillary endothelial vessels expressing CD31 or CD34, possibly reflecting the unique imaging pattern in the late vascular phase of CE-US, which has been reported in choangiolocellular carcinoma. In addition, we reviewed which kind of treatment would be suitable for advanced hepatic primary SCC in the literature. From the review, it could be proposed that a combination of radiation therapy, systemic chemotherapy (5-FU and CDDP) and surgical resection, if possible, is appropriate for advanced primary SCC of the liver. |
format | Online Article Text |
id | pubmed-3237109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | S. Karger AG |
record_format | MEDLINE/PubMed |
spelling | pubmed-32371092011-12-14 Primary Squamous Cell Carcinoma of the Liver: An Uncommon Finding in Contrast-Enhanced Ultrasonography Imaging Iimuro, Yuji Asano, Yasukane Suzumura, Kazuhiro Yada, Akito Hirano, Tadamichi Iijima, Hiroko Nishiguchi, Shuhei Hirota, Seiichi Fujimoto, Jiro Case Rep Gastroenterol Published: November, 2011 Primary squamous cell carcinoma (SCC) of the liver is rare tumor with an unfavorable prognosis. We report a case of advanced primary SCC of the liver arising adjacent to a nonparasitic liver cyst, invading into the right diaphragm and the right lung tissue. Contrast-enhanced ultrasonography (CE-US) demonstrated unique enhancement in the late vascular phase, which was incompatible with those observed in hepatocellular carcinoma, cholangiocellular carcinoma, or metastatic adenocarcinoma. The patient underwent surgical resection of the tumor followed by systemic chemotherapy with 5-fluorouracil (5-FU) and cisplatin (CDDP), while radiation chemotherapy was not applied because of relatively poor performance status. Although postoperative image analysis revealed no recurrence 4 months later, the patient died 13 months after the operation from recurrence. Immunohistological analysis of the resected specimen revealed that this SCC contained many capillary endothelial vessels expressing CD31 or CD34, possibly reflecting the unique imaging pattern in the late vascular phase of CE-US, which has been reported in choangiolocellular carcinoma. In addition, we reviewed which kind of treatment would be suitable for advanced hepatic primary SCC in the literature. From the review, it could be proposed that a combination of radiation therapy, systemic chemotherapy (5-FU and CDDP) and surgical resection, if possible, is appropriate for advanced primary SCC of the liver. S. Karger AG 2011-11-05 /pmc/articles/PMC3237109/ /pubmed/22171214 http://dx.doi.org/10.1159/000334425 Text en Copyright © 2011 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No-Derivative-Works License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Users may download, print and share this work on the Internet for noncommercial purposes only, provided the original work is properly cited, and a link to the original work on http://www.karger.com and the terms of this license are included in any shared versions. |
spellingShingle | Published: November, 2011 Iimuro, Yuji Asano, Yasukane Suzumura, Kazuhiro Yada, Akito Hirano, Tadamichi Iijima, Hiroko Nishiguchi, Shuhei Hirota, Seiichi Fujimoto, Jiro Primary Squamous Cell Carcinoma of the Liver: An Uncommon Finding in Contrast-Enhanced Ultrasonography Imaging |
title | Primary Squamous Cell Carcinoma of the Liver: An Uncommon Finding in Contrast-Enhanced Ultrasonography Imaging |
title_full | Primary Squamous Cell Carcinoma of the Liver: An Uncommon Finding in Contrast-Enhanced Ultrasonography Imaging |
title_fullStr | Primary Squamous Cell Carcinoma of the Liver: An Uncommon Finding in Contrast-Enhanced Ultrasonography Imaging |
title_full_unstemmed | Primary Squamous Cell Carcinoma of the Liver: An Uncommon Finding in Contrast-Enhanced Ultrasonography Imaging |
title_short | Primary Squamous Cell Carcinoma of the Liver: An Uncommon Finding in Contrast-Enhanced Ultrasonography Imaging |
title_sort | primary squamous cell carcinoma of the liver: an uncommon finding in contrast-enhanced ultrasonography imaging |
topic | Published: November, 2011 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237109/ https://www.ncbi.nlm.nih.gov/pubmed/22171214 http://dx.doi.org/10.1159/000334425 |
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