Fatal Disseminated Cryptococcus gattii Infection in New Mexico

We report a case of fatal disseminated infection with Cryptococcus gattii in a patient from New Mexico. The patient had no history of recent travel to known C. gattii-endemic areas. Multilocus sequence typing revealed that the isolate belonged to the major molecular type VGIII. Virulence studies in...

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Detalles Bibliográficos
Autores principales: Walraven, Carla J., Gerstein, Wendy, Hardison, Sarah E., Wormley, Floyd, Lockhart, Shawn R., Harris, Julie R., Fothergill, Annette, Wickes, Brian, Gober-Wilcox, Julie, Massie, Larry, Ku, T. S. Neil, Firacative, Carolina, Meyer, Wieland, Lee, Samuel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237461/
https://www.ncbi.nlm.nih.gov/pubmed/22194869
http://dx.doi.org/10.1371/journal.pone.0028625
Descripción
Sumario:We report a case of fatal disseminated infection with Cryptococcus gattii in a patient from New Mexico. The patient had no history of recent travel to known C. gattii-endemic areas. Multilocus sequence typing revealed that the isolate belonged to the major molecular type VGIII. Virulence studies in a mouse pulmonary model of infection demonstrated that the strain was less virulent than other C. gattii strains. This represents the first documented case of C. gattii likely acquired in New Mexico.

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