Systems Biology Modeling Reveals a Possible Mechanism of the Tumor Cell Death upon Oncogene Inactivation in EGFR Addicted Cancers

Despite many evidences supporting the concept of “oncogene addiction” and many hypotheses rationalizing it, there is still a lack of detailed understanding to the precise molecular mechanism underlying oncogene addiction. In this account, we developed a mathematic model of epidermal growth factor re...

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Detalles Bibliográficos
Autores principales: Zhou, Jian-Ping, Chen, Xin, Feng, Shan, Luo, Shi-Dong, Pan, You-Li, Zhong, Lei, Ji, Pan, Wang, Ze-Rong, Ma, Shuang, Li, Lin-Li, Wei, Yu-Quan, Yang, Sheng-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237568/
https://www.ncbi.nlm.nih.gov/pubmed/22194952
http://dx.doi.org/10.1371/journal.pone.0028930

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