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Characterization of the role of COP9 signalosome in regulating cullin E3 ubiquitin ligase activity

Cullin RING ligases (CRLs) are the largest family of cellular E3 ubiquitin ligases and mediate polyubiquitination of a number of cellular substrates. CRLs are activated via the covalent modification of the cullin protein with the ubiquitin-like protein Nedd8. This results in a conformational change...

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Detalles Bibliográficos
Autores principales:	Choo, Yin Yin, Boh, Boon Kim, Lou, Jessica Jie Wei, Eng, Jolane, Leck, Yee Chin, Anders, Benjamin, Smith, Peter G., Hagen, Thilo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2011
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237615/ https://www.ncbi.nlm.nih.gov/pubmed/22013077 http://dx.doi.org/10.1091/mbc.E11-03-0251

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