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Sequestration of phosphoinositides by mutated MARCKS effector domain inhibits stimulated Ca(2+) mobilization and degranulation in mast cells

Protein kinase C β (PKCβ) participates in antigen-stimulated mast cell degranulation mediated by the high-affinity receptor for immunoglobulin E, FcεRI, but the molecular basis is unclear. We investigated the hypothesis that the polybasic effector domain (ED) of the abundant intracellular substrate...

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Detalles Bibliográficos
Autores principales:	Gadi, Deepti, Wagenknecht-Wiesner, Alice, Holowka, David, Baird, Barbara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2011
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237632/ https://www.ncbi.nlm.nih.gov/pubmed/22013076 http://dx.doi.org/10.1091/mbc.E11-07-0614

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