Cargando…

Endoplasmic Reticulum Stress Inhibits STAT3-Dependent Suppression of Hepatic Gluconeogenesis via Dephosphorylation and Deacetylation

In the liver, signal transducer and activator of transcription 3 (STAT3) plays an important role in the suppression of gluconeogenic enzyme expression. While obesity-associated endoplasmic reticulum (ER) stress has been shown to increase hepatic gluconeogenic enzyme expression, the role of ER stress...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kimura, Kumi, Yamada, Tomoko, Matsumoto, Michihiro, Kido, Yoshiaki, Hosooka, Tetsuya, Asahara, Shun-ichiro, Matsuda, Tomokazu, Ota, Tsuguhito, Watanabe, Hiroshi, Sai, Yoshimichi, Miyamoto, Kenichi, Kaneko, Shuichi, Kasuga, Masato, Inoue, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2012
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237645/ https://www.ncbi.nlm.nih.gov/pubmed/22124464 http://dx.doi.org/10.2337/db10-1684

Ejemplares similares

Histidine Augments the Suppression of Hepatic Glucose Production by Central Insulin Action
por: Kimura, Kumi, et al.
Publicado: (2013)

Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein
por: Watanabe, Hitoshi, et al.
Publicado: (2018)

PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes
por: Yano, Hiroyuki, et al.
Publicado: (2018)

Ablation of TSC2 Enhances Insulin Secretion by Increasing the Number of Mitochondria through Activation of mTORC1
por: Koyanagi, Maki, et al.
Publicado: (2011)

A novel role for the cell cycle regulatory complex cyclin D1–CDK4 in gluconeogenesis
por: Hosooka, Tetsuya, et al.
Publicado: (2015)

CCR5 Plays a Critical Role in Obesity-Induced Adipose Tissue Inflammation and Insulin Resistance by Regulating Both Macrophage Recruitment and M1/M2 Status
por: Kitade, Hironori, et al.
Publicado: (2012)

Regulation of Pancreatic β Cell Mass by Cross-Interaction between CCAAT Enhancer Binding Protein β Induced by Endoplasmic Reticulum Stress and AMP-Activated Protein Kinase Activity
por: Matsuda, Tomokazu, et al.
Publicado: (2015)

Role of KLF15 in Regulation of Hepatic Gluconeogenesis and Metformin Action
por: Takashima, Mototsugu, et al.
Publicado: (2010)

ERK Dephosphorylation through MKP1 Deacetylation by SIRT1 Attenuates RAS-Driven Tumorigenesis
por: Kwon, Ok-Seon, et al.
Publicado: (2020)

Acute Endoplasmic Reticulum Stress Suppresses Hepatic Gluconeogenesis by Stimulating MAPK Phosphatase 3 Degradation
por: Huang, Xiaohua, et al.
Publicado: (2023)

Statin-activated nuclear receptor PXR promotes SGK2 dephosphorylation by scaffolding PP2C to induce hepatic gluconeogenesis
por: Gotoh, Saki, et al.
Publicado: (2015)

Proteasome Dysfunction Mediates Obesity-Induced Endoplasmic Reticulum Stress and Insulin Resistance in the Liver
por: Otoda, Toshiki, et al.
Publicado: (2013)

A Reduction in Age-Enhanced Gluconeogenesis Extends Lifespan
por: Hachinohe, Mayumi, et al.
Publicado: (2013)

Septin4 Prevents PDGF-BB-induced HAVSMC Phenotypic Transformation, Proliferation and Migration by Promoting SIRT1-STAT3 Deacetylation and Dephosphorylation
por: Zhang, Naijin, et al.
Publicado: (2020)

The transcription factor ATF3 switches cell death from apoptosis to necroptosis in hepatic steatosis in male mice
por: Inaba, Yuka, et al.
Publicado: (2023)

Cerebral Gluconeogenesis and Diseases
por: Yip, James, et al.
Publicado: (2017)

Lipopolysaccharide inhibits hepatic gluconeogenesis in rats: The role of immune cells
por: Tanaka, Hiroshi, et al.
Publicado: (2017)

Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin
por: Asahara, S., et al.
Publicado: (2013)

Inhibition of Phosphodiesterase-4 (PDE4) activity triggers luminal apoptosis and AKT dephosphorylation in a 3-D colonic-crypt model
por: Tsunoda, Toshiyuki, et al.
Publicado: (2012)

Ursodeoxycholic acid potentiates dipeptidyl peptidase-4 inhibitor sitagliptin by enhancing glucagon-like peptide-1 secretion in patients with type 2 diabetes and chronic liver disease: a pilot randomized controlled and add-on study
por: Shima, Kosuke Robert, et al.
Publicado: (2018)

Reply to the Letter to the Editor by Li et al.: Bioinformatics Analysis in Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E
por: Kobori, Masuko, et al.
Publicado: (2017)

Hepatic Transcriptome Profiles of Mice with Diet-Induced Nonalcoholic Steatohepatitis Treated with Astaxanthin and Vitamin E
por: Kobori, Masuko, et al.
Publicado: (2017)

CCR5: A novel player in the adipose tissue inflammation and insulin resistance?
por: Ota, Tsuguhito
Publicado: (2013)

Chemokine Systems Link Obesity to Insulin Resistance
por: Ota, Tsuguhito
Publicado: (2013)

Obesity-Induced Inflammation and Insulin Resistance
por: Ota, Tsuguhito
Publicado: (2014)

Deacetylate to differentiate
por: LeBrasseur, Nicole
Publicado: (2005)

Unraveling the Regulation of Hepatic Gluconeogenesis
por: Zhang, Xueping, et al.
Publicado: (2019)

The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch
por: Sakai, Mashito, et al.
Publicado: (2016)

Brown adipocyte-specific knockout of Bmal1 causes mild but significant thermogenesis impairment in mice
por: Hasan, Nazmul, et al.
Publicado: (2021)

Inverse Correlation between Serum Levels of Selenoprotein P and Adiponectin in Patients with Type 2 Diabetes
por: Misu, Hirofumi, et al.
Publicado: (2012)

Astaxanthin prevents and reverses diet-induced insulin resistance and steatohepatitis in mice: A comparison with vitamin E
por: Ni, Yinhua, et al.
Publicado: (2015)

SGLT2 Inhibition by Empagliflozin Promotes Fat Utilization and Browning and Attenuates Inflammation and Insulin Resistance by Polarizing M2 Macrophages in Diet-induced Obese Mice
por: Xu, Liang, et al.
Publicado: (2017)

Empagliflozin reverses obesity and insulin resistance through fat browning and alternative macrophage activation in mice fed a high-fat diet
por: Xu, Liang, et al.
Publicado: (2019)

Palmitate Induces Insulin Resistance in H4IIEC3 Hepatocytes through Reactive Oxygen Species Produced by Mitochondria
por: Nakamura, Seiji, et al.
Publicado: (2009)

Endoplasmic reticulum stress and diabetic retinopathy
por: Oshitari, Toshiyuki, et al.
Publicado: (2008)

The combination of NAD(+)-dependent deacetylase gene deletion and the interruption of gluconeogenesis causes increased glucose metabolism in budding yeast
por: Masumoto, Hiroshi, et al.
Publicado: (2018)

Acetylation, deacetylation and acyltransfer
por: King, Charles M., et al.
Publicado: (1983)

Deacetylnomilin monohydrate
por: Li, Guo-Qiang, et al.
Publicado: (2011)

Deacetyl tenuazonic acid
por: Siegel, David, et al.
Publicado: (2009)

7-Deacetylgedunin
por: Ravangpai, Warin, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_i9cbhlefaphn5cti1fr1ndr61p