Single-cell dissection of transcriptional heterogeneity in human colon tumors

Cancer is often viewed as a caricature of normal developmental processes, but the extent by which its cellular heterogeneity truly recapitulates multi-lineage differentiation processes of normal tissues remains unknown. Here, we implement “single-cell PCR gene-expression analysis” (SINCE-PCR) to dis...

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Detalles Bibliográficos
Autores principales: Dalerba, Piero, Kalisky, Tomer, Sahoo, Debashis, Rajendran, Pradeep S., Rothenberg, Michael E., Leyrat, Anne A., Sim, Sopheak, Okamoto, Jennifer, Johnston, Darius M., Qian, Dalong, Zabala, Maider, Bueno, Janet, Neff, Norma F., Wang, Jianbin, Shelton, Andrew A., Visser, Brendan, Hisamori, Shigeo, Shimono, Yohei, van de Wetering, Marc, Clevers, Hans, Clarke, Michael F., Quake, Stephen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237928/
https://www.ncbi.nlm.nih.gov/pubmed/22081019
http://dx.doi.org/10.1038/nbt.2038

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