Cargando…

Autoantibodies in rheumatoid arthritis and their clinical significance

Autoantibodies are proven useful diagnostic tools for a variety of rheumatic and non-rheumatic autoimmune disorders. However, a highly specific marker autoantibody for rheumatoid arthritis (RA) has not yet been determined. The presence of rheumatoid factors is currently used as a marker for RA. Howe...

Descripción completa

Detalles Bibliográficos
Autores principales: Steiner, Günter, Smolen, Josef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2002
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238219/
https://www.ncbi.nlm.nih.gov/pubmed/12110150
http://dx.doi.org/10.1186/ar551
_version_ 1782218963395018752
author Steiner, Günter
Smolen, Josef
author_facet Steiner, Günter
Smolen, Josef
author_sort Steiner, Günter
collection PubMed
description Autoantibodies are proven useful diagnostic tools for a variety of rheumatic and non-rheumatic autoimmune disorders. However, a highly specific marker autoantibody for rheumatoid arthritis (RA) has not yet been determined. The presence of rheumatoid factors is currently used as a marker for RA. However, rheumatoid factors have modest specificity (~70%) for the disease. In recent years, several newly characterized autoantibodies have become promising candidates as diagnostic indicators for RA. Antikeratin, anticitrullinated peptides, anti-RA33, anti-Sa, and anti-p68 autoantibodies have been shown to have >90% specificity for RA. These autoantibodies are reviewed and the potential role of the autoantibodies in the pathogenesis of RA is briefly discussed.
format Online
Article
Text
id pubmed-3238219
institution National Center for Biotechnology Information
language English
publishDate 2002
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-32382192011-12-16 Autoantibodies in rheumatoid arthritis and their clinical significance Steiner, Günter Smolen, Josef Arthritis Res Supplement Autoantibodies are proven useful diagnostic tools for a variety of rheumatic and non-rheumatic autoimmune disorders. However, a highly specific marker autoantibody for rheumatoid arthritis (RA) has not yet been determined. The presence of rheumatoid factors is currently used as a marker for RA. However, rheumatoid factors have modest specificity (~70%) for the disease. In recent years, several newly characterized autoantibodies have become promising candidates as diagnostic indicators for RA. Antikeratin, anticitrullinated peptides, anti-RA33, anti-Sa, and anti-p68 autoantibodies have been shown to have >90% specificity for RA. These autoantibodies are reviewed and the potential role of the autoantibodies in the pathogenesis of RA is briefly discussed. BioMed Central 2002 2002-04-26 /pmc/articles/PMC3238219/ /pubmed/12110150 http://dx.doi.org/10.1186/ar551 Text en Copyright ©2002 BioMed Central Ltd
spellingShingle Supplement
Steiner, Günter
Smolen, Josef
Autoantibodies in rheumatoid arthritis and their clinical significance
title Autoantibodies in rheumatoid arthritis and their clinical significance
title_full Autoantibodies in rheumatoid arthritis and their clinical significance
title_fullStr Autoantibodies in rheumatoid arthritis and their clinical significance
title_full_unstemmed Autoantibodies in rheumatoid arthritis and their clinical significance
title_short Autoantibodies in rheumatoid arthritis and their clinical significance
title_sort autoantibodies in rheumatoid arthritis and their clinical significance
topic Supplement
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238219/
https://www.ncbi.nlm.nih.gov/pubmed/12110150
http://dx.doi.org/10.1186/ar551
work_keys_str_mv AT steinergunter autoantibodiesinrheumatoidarthritisandtheirclinicalsignificance
AT smolenjosef autoantibodiesinrheumatoidarthritisandtheirclinicalsignificance