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Late-onset peritoneal recurrence of advanced gastric cancer 20 years after primary resection
Late onset of peritoneal recurrence of gastric cancer more than 10 years after surgery is extremely rare, and only three cases have been reported. We present the case of a 61-year-old man who was diagnosed finally with peritoneal recurrence of gastric cancer 20 years after primary curative resection...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238290/ https://www.ncbi.nlm.nih.gov/pubmed/21092332 http://dx.doi.org/10.1186/1477-7819-8-104 |
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author | Okugawa, Yoshinaga Toiyama, Yuji Inoue, Yasuhiro Saigusa, Susumu Kobayashi, Minako Tanaka, Koji Mohri, Yasuhiko Miki, Chikao Kusunoki, Masato |
author_facet | Okugawa, Yoshinaga Toiyama, Yuji Inoue, Yasuhiro Saigusa, Susumu Kobayashi, Minako Tanaka, Koji Mohri, Yasuhiko Miki, Chikao Kusunoki, Masato |
author_sort | Okugawa, Yoshinaga |
collection | PubMed |
description | Late onset of peritoneal recurrence of gastric cancer more than 10 years after surgery is extremely rare, and only three cases have been reported. We present the case of a 61-year-old man who was diagnosed finally with peritoneal recurrence of gastric cancer 20 years after primary curative resection. As a result of small-bowel obstruction caused by peritoneal recurrence, diverting ileostomy with partial ileal resection was performed. The resected specimen revealed tubular adenocarcinoma that resembled the primary gastric cancer. The clinical course after the second operation was unfavorable and systemic chemotherapy had no effect. He died at 62 years of age, 21 years and 7 months after initial gastrectomy. Immunohistochemical analysis using antibodies against proliferating cell nuclear antigen (PCNA), Ki-67, and p53 was performed to investigate the phenotype of primary and recurrence cancer. Protein expression of proliferation markers such as PCNA and Ki-67 was down-regulated, but p53 was overexpressed at the site of recurrence. These data suggest that late peritoneal recurrence has a low proliferation rate and is resistant to chemoradiotherapy. In conclusion, we present late onset of peritoneal recurrence of gastric cancer more than 20 years after primary surgery, and speculate on the mechanism of late-onset recurrence in our case. |
format | Online Article Text |
id | pubmed-3238290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32382902011-12-16 Late-onset peritoneal recurrence of advanced gastric cancer 20 years after primary resection Okugawa, Yoshinaga Toiyama, Yuji Inoue, Yasuhiro Saigusa, Susumu Kobayashi, Minako Tanaka, Koji Mohri, Yasuhiko Miki, Chikao Kusunoki, Masato World J Surg Oncol Case Report Late onset of peritoneal recurrence of gastric cancer more than 10 years after surgery is extremely rare, and only three cases have been reported. We present the case of a 61-year-old man who was diagnosed finally with peritoneal recurrence of gastric cancer 20 years after primary curative resection. As a result of small-bowel obstruction caused by peritoneal recurrence, diverting ileostomy with partial ileal resection was performed. The resected specimen revealed tubular adenocarcinoma that resembled the primary gastric cancer. The clinical course after the second operation was unfavorable and systemic chemotherapy had no effect. He died at 62 years of age, 21 years and 7 months after initial gastrectomy. Immunohistochemical analysis using antibodies against proliferating cell nuclear antigen (PCNA), Ki-67, and p53 was performed to investigate the phenotype of primary and recurrence cancer. Protein expression of proliferation markers such as PCNA and Ki-67 was down-regulated, but p53 was overexpressed at the site of recurrence. These data suggest that late peritoneal recurrence has a low proliferation rate and is resistant to chemoradiotherapy. In conclusion, we present late onset of peritoneal recurrence of gastric cancer more than 20 years after primary surgery, and speculate on the mechanism of late-onset recurrence in our case. BioMed Central 2010-11-24 /pmc/articles/PMC3238290/ /pubmed/21092332 http://dx.doi.org/10.1186/1477-7819-8-104 Text en Copyright ©2010 Okugawa et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Okugawa, Yoshinaga Toiyama, Yuji Inoue, Yasuhiro Saigusa, Susumu Kobayashi, Minako Tanaka, Koji Mohri, Yasuhiko Miki, Chikao Kusunoki, Masato Late-onset peritoneal recurrence of advanced gastric cancer 20 years after primary resection |
title | Late-onset peritoneal recurrence of advanced gastric cancer 20 years after primary resection |
title_full | Late-onset peritoneal recurrence of advanced gastric cancer 20 years after primary resection |
title_fullStr | Late-onset peritoneal recurrence of advanced gastric cancer 20 years after primary resection |
title_full_unstemmed | Late-onset peritoneal recurrence of advanced gastric cancer 20 years after primary resection |
title_short | Late-onset peritoneal recurrence of advanced gastric cancer 20 years after primary resection |
title_sort | late-onset peritoneal recurrence of advanced gastric cancer 20 years after primary resection |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238290/ https://www.ncbi.nlm.nih.gov/pubmed/21092332 http://dx.doi.org/10.1186/1477-7819-8-104 |
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