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Regulating Caspase-1 During Infection: Roles of NLRs, AIM2, and ASC
Pathogens are detected by a variety of innate immune sensors in host cells leading to rapid induction of cell autonomous responses. Proinflammatory cytokine secretion and a specialized form of inflammatory cell death called pyroptosis are induced during infection through activation of caspase-1. Pat...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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YJBM
2011
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238316/ https://www.ncbi.nlm.nih.gov/pubmed/22180671 |
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author | Case, Christopher L. |
author_facet | Case, Christopher L. |
author_sort | Case, Christopher L. |
collection | PubMed |
description | Pathogens are detected by a variety of innate immune sensors in host cells leading to rapid induction of cell autonomous responses. Proinflammatory cytokine secretion and a specialized form of inflammatory cell death called pyroptosis are induced during infection through activation of caspase-1. Pathogen-induced caspase-1 activation is regulated in large part by a vast array of cystosolic sensor proteins, including NLRs and AIM2, and an adaptor protein called ASC. Together, these proteins cooperate in forming caspase-1 activation platforms and, more importantly, direct caspase-1 toward cytokine secretion or cell death. |
format | Online Article Text |
id | pubmed-3238316 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | YJBM |
record_format | MEDLINE/PubMed |
spelling | pubmed-32383162011-12-16 Regulating Caspase-1 During Infection: Roles of NLRs, AIM2, and ASC Case, Christopher L. Yale J Biol Med Focus: Immunology and Immunotherapeutics Pathogens are detected by a variety of innate immune sensors in host cells leading to rapid induction of cell autonomous responses. Proinflammatory cytokine secretion and a specialized form of inflammatory cell death called pyroptosis are induced during infection through activation of caspase-1. Pathogen-induced caspase-1 activation is regulated in large part by a vast array of cystosolic sensor proteins, including NLRs and AIM2, and an adaptor protein called ASC. Together, these proteins cooperate in forming caspase-1 activation platforms and, more importantly, direct caspase-1 toward cytokine secretion or cell death. YJBM 2011-12 2011-12 /pmc/articles/PMC3238316/ /pubmed/22180671 Text en Copyright ©2011, Yale Journal of Biology and Medicine https://creativecommons.org/licenses/by-nc/3.0/This is an open access article distributed under the terms of the Creative Commons CC BY-NC license, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use the material for commercial purposes. |
spellingShingle | Focus: Immunology and Immunotherapeutics Case, Christopher L. Regulating Caspase-1 During Infection: Roles of NLRs, AIM2, and ASC |
title | Regulating Caspase-1 During Infection: Roles of NLRs, AIM2, and ASC |
title_full | Regulating Caspase-1 During Infection: Roles of NLRs, AIM2, and ASC |
title_fullStr | Regulating Caspase-1 During Infection: Roles of NLRs, AIM2, and ASC |
title_full_unstemmed | Regulating Caspase-1 During Infection: Roles of NLRs, AIM2, and ASC |
title_short | Regulating Caspase-1 During Infection: Roles of NLRs, AIM2, and ASC |
title_sort | regulating caspase-1 during infection: roles of nlrs, aim2, and asc |
topic | Focus: Immunology and Immunotherapeutics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238316/ https://www.ncbi.nlm.nih.gov/pubmed/22180671 |
work_keys_str_mv | AT casechristopherl regulatingcaspase1duringinfectionrolesofnlrsaim2andasc |