Phosphatidylinositol 4,5-bisphosphate (PIP(2)) controls magnesium gatekeeper TRPM6 activity

TRPM6 is crucial for human Mg(2+) homeostasis as patients carrying TRPM6 mutations develop hypomagnesemia and secondary hypocalcemia (HSH). However, the activation mechanism of TRPM6 has remained unknown. Here we demonstrate that phosphatidylinositol-4,5-bisphophate (PIP(2)) controls TRPM6 activatio...

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Detalles Bibliográficos
Autores principales: Xie, Jia, Sun, Baonan, Du, Jianyang, Yang, Wenzhong, Chen, Hsiang-Chin, Overton, Jeffrey D., Runnels, Loren W., Yue, Lixia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238349/
https://www.ncbi.nlm.nih.gov/pubmed/22180838
http://dx.doi.org/10.1038/srep00146

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