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The Role of Metformin in the Management of NAFLD

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide. Its prevalence ranges 10–24% in the general population, reaching 60–95% and 28–55% in obese and diabetic patients, respectively. Although the etiology of NAFLD is still unclear, several lines of evidences have indi...

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Autores principales: Mazza, Angela, Fruci, Barbara, Garinis, Giorgia Anna, Giuliano, Stefania, Malaguarnera, Roberta, Belfiore, Antonino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238361/
https://www.ncbi.nlm.nih.gov/pubmed/22194737
http://dx.doi.org/10.1155/2012/716404
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author Mazza, Angela
Fruci, Barbara
Garinis, Giorgia Anna
Giuliano, Stefania
Malaguarnera, Roberta
Belfiore, Antonino
author_facet Mazza, Angela
Fruci, Barbara
Garinis, Giorgia Anna
Giuliano, Stefania
Malaguarnera, Roberta
Belfiore, Antonino
author_sort Mazza, Angela
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide. Its prevalence ranges 10–24% in the general population, reaching 60–95% and 28–55% in obese and diabetic patients, respectively. Although the etiology of NAFLD is still unclear, several lines of evidences have indicated a pathogenetic role of insulin resistance in this disorder. This concept has stimulated several clinical studies where antidiabetic drugs, such as insulin sensitizers including metformin, have been evaluated in insulin-resistant, NAFLD patients. These studies indicate that metformin might be of benefit in the treatment of NAFLD, also in nondiabetic patients, when associated to hypocaloric diet and weight control. However, the heterogeneity of these studies still prevents us from reaching firm conclusions about treatment guidelines. Moreover, metformin could have beneficial tissue-specific effects in NAFLD patients irrespective of its effects as insulin sensitizer.
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spelling pubmed-32383612011-12-22 The Role of Metformin in the Management of NAFLD Mazza, Angela Fruci, Barbara Garinis, Giorgia Anna Giuliano, Stefania Malaguarnera, Roberta Belfiore, Antonino Exp Diabetes Res Review Article Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder worldwide. Its prevalence ranges 10–24% in the general population, reaching 60–95% and 28–55% in obese and diabetic patients, respectively. Although the etiology of NAFLD is still unclear, several lines of evidences have indicated a pathogenetic role of insulin resistance in this disorder. This concept has stimulated several clinical studies where antidiabetic drugs, such as insulin sensitizers including metformin, have been evaluated in insulin-resistant, NAFLD patients. These studies indicate that metformin might be of benefit in the treatment of NAFLD, also in nondiabetic patients, when associated to hypocaloric diet and weight control. However, the heterogeneity of these studies still prevents us from reaching firm conclusions about treatment guidelines. Moreover, metformin could have beneficial tissue-specific effects in NAFLD patients irrespective of its effects as insulin sensitizer. Hindawi Publishing Corporation 2012 2011-12-12 /pmc/articles/PMC3238361/ /pubmed/22194737 http://dx.doi.org/10.1155/2012/716404 Text en Copyright © 2012 Angela Mazza et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mazza, Angela
Fruci, Barbara
Garinis, Giorgia Anna
Giuliano, Stefania
Malaguarnera, Roberta
Belfiore, Antonino
The Role of Metformin in the Management of NAFLD
title The Role of Metformin in the Management of NAFLD
title_full The Role of Metformin in the Management of NAFLD
title_fullStr The Role of Metformin in the Management of NAFLD
title_full_unstemmed The Role of Metformin in the Management of NAFLD
title_short The Role of Metformin in the Management of NAFLD
title_sort role of metformin in the management of nafld
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238361/
https://www.ncbi.nlm.nih.gov/pubmed/22194737
http://dx.doi.org/10.1155/2012/716404
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