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The Actin-Bundling Protein L-Plastin: A Critical Regulator of Immune Cell Function
L-plastin is a leukocyte-specific protein that cross-links actin filaments into tight bundles, increasing the stability of actin-based structures such as podosomes and lamellipodia. While first identified as an abundant cytoplasmic protein in hematopoietically derived cells over 25 years ago, the re...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238366/ https://www.ncbi.nlm.nih.gov/pubmed/22194750 http://dx.doi.org/10.1155/2012/935173 |
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author | Morley, Sharon Celeste |
author_facet | Morley, Sharon Celeste |
author_sort | Morley, Sharon Celeste |
collection | PubMed |
description | L-plastin is a leukocyte-specific protein that cross-links actin filaments into tight bundles, increasing the stability of actin-based structures such as podosomes and lamellipodia. While first identified as an abundant cytoplasmic protein in hematopoietically derived cells over 25 years ago, the requirement for L-plastin in multiple functions critical for immunity, such as antigen receptor signaling, adhesion, and motility, has only recently become clear. L-plastin has been identified as an important component in cellular processes critical for neutrophil, macrophage, osteoclast, eosinophil, and T- and B-lymphocyte biology. Following a brief description of the structure and function of L-plastin, the regulation of immune cell functions by L-plastin will be reviewed in detail. |
format | Online Article Text |
id | pubmed-3238366 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32383662011-12-22 The Actin-Bundling Protein L-Plastin: A Critical Regulator of Immune Cell Function Morley, Sharon Celeste Int J Cell Biol Review Article L-plastin is a leukocyte-specific protein that cross-links actin filaments into tight bundles, increasing the stability of actin-based structures such as podosomes and lamellipodia. While first identified as an abundant cytoplasmic protein in hematopoietically derived cells over 25 years ago, the requirement for L-plastin in multiple functions critical for immunity, such as antigen receptor signaling, adhesion, and motility, has only recently become clear. L-plastin has been identified as an important component in cellular processes critical for neutrophil, macrophage, osteoclast, eosinophil, and T- and B-lymphocyte biology. Following a brief description of the structure and function of L-plastin, the regulation of immune cell functions by L-plastin will be reviewed in detail. Hindawi Publishing Corporation 2012 2011-12-13 /pmc/articles/PMC3238366/ /pubmed/22194750 http://dx.doi.org/10.1155/2012/935173 Text en Copyright © 2012 Sharon Celeste Morley. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Morley, Sharon Celeste The Actin-Bundling Protein L-Plastin: A Critical Regulator of Immune Cell Function |
title | The Actin-Bundling Protein L-Plastin: A Critical Regulator of Immune Cell Function |
title_full | The Actin-Bundling Protein L-Plastin: A Critical Regulator of Immune Cell Function |
title_fullStr | The Actin-Bundling Protein L-Plastin: A Critical Regulator of Immune Cell Function |
title_full_unstemmed | The Actin-Bundling Protein L-Plastin: A Critical Regulator of Immune Cell Function |
title_short | The Actin-Bundling Protein L-Plastin: A Critical Regulator of Immune Cell Function |
title_sort | actin-bundling protein l-plastin: a critical regulator of immune cell function |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238366/ https://www.ncbi.nlm.nih.gov/pubmed/22194750 http://dx.doi.org/10.1155/2012/935173 |
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