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The Actin-Bundling Protein L-Plastin: A Critical Regulator of Immune Cell Function

L-plastin is a leukocyte-specific protein that cross-links actin filaments into tight bundles, increasing the stability of actin-based structures such as podosomes and lamellipodia. While first identified as an abundant cytoplasmic protein in hematopoietically derived cells over 25 years ago, the re...

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Detalles Bibliográficos
Autor principal: Morley, Sharon Celeste
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238366/
https://www.ncbi.nlm.nih.gov/pubmed/22194750
http://dx.doi.org/10.1155/2012/935173
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author Morley, Sharon Celeste
author_facet Morley, Sharon Celeste
author_sort Morley, Sharon Celeste
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description L-plastin is a leukocyte-specific protein that cross-links actin filaments into tight bundles, increasing the stability of actin-based structures such as podosomes and lamellipodia. While first identified as an abundant cytoplasmic protein in hematopoietically derived cells over 25 years ago, the requirement for L-plastin in multiple functions critical for immunity, such as antigen receptor signaling, adhesion, and motility, has only recently become clear. L-plastin has been identified as an important component in cellular processes critical for neutrophil, macrophage, osteoclast, eosinophil, and T- and B-lymphocyte biology. Following a brief description of the structure and function of L-plastin, the regulation of immune cell functions by L-plastin will be reviewed in detail.
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spelling pubmed-32383662011-12-22 The Actin-Bundling Protein L-Plastin: A Critical Regulator of Immune Cell Function Morley, Sharon Celeste Int J Cell Biol Review Article L-plastin is a leukocyte-specific protein that cross-links actin filaments into tight bundles, increasing the stability of actin-based structures such as podosomes and lamellipodia. While first identified as an abundant cytoplasmic protein in hematopoietically derived cells over 25 years ago, the requirement for L-plastin in multiple functions critical for immunity, such as antigen receptor signaling, adhesion, and motility, has only recently become clear. L-plastin has been identified as an important component in cellular processes critical for neutrophil, macrophage, osteoclast, eosinophil, and T- and B-lymphocyte biology. Following a brief description of the structure and function of L-plastin, the regulation of immune cell functions by L-plastin will be reviewed in detail. Hindawi Publishing Corporation 2012 2011-12-13 /pmc/articles/PMC3238366/ /pubmed/22194750 http://dx.doi.org/10.1155/2012/935173 Text en Copyright © 2012 Sharon Celeste Morley. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Morley, Sharon Celeste
The Actin-Bundling Protein L-Plastin: A Critical Regulator of Immune Cell Function
title The Actin-Bundling Protein L-Plastin: A Critical Regulator of Immune Cell Function
title_full The Actin-Bundling Protein L-Plastin: A Critical Regulator of Immune Cell Function
title_fullStr The Actin-Bundling Protein L-Plastin: A Critical Regulator of Immune Cell Function
title_full_unstemmed The Actin-Bundling Protein L-Plastin: A Critical Regulator of Immune Cell Function
title_short The Actin-Bundling Protein L-Plastin: A Critical Regulator of Immune Cell Function
title_sort actin-bundling protein l-plastin: a critical regulator of immune cell function
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238366/
https://www.ncbi.nlm.nih.gov/pubmed/22194750
http://dx.doi.org/10.1155/2012/935173
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