Liver Glucokinase(A456V) Induces Potent Hypoglycemia without Dyslipidemia through a Paradoxical Induction of the Catalytic Subunit of Glucose-6-Phosphatase

Recent reports point out the importance of the complex GK-GKRP in controlling glucose and lipid homeostasis. Several GK mutations affect GKRP binding, resulting in permanent activation of the enzyme. We hypothesize that hepatic overexpression of a mutated form of GK, GK(A456V), described in a patien...

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Detalles Bibliográficos
Autores principales: Vidal-Alabró, Anna, Gómez-Valadés, Alícia G., Méndez-Lucas, Andrés, Llorens, Jordi, Bartrons, Ramon, Bermúdez, Jordi, Perales, Jose C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238378/
https://www.ncbi.nlm.nih.gov/pubmed/22194744
http://dx.doi.org/10.1155/2011/707928

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