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Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease
Parkinson's disease (PD) is associated with various nonmotor symptoms including neuropsychiatric and cognitive dysfunction. We examined the relation between apathy, anxiety, side of onset of motor symptoms, and cognition in PD. We hypothesized that PD patients would show different neuropsychiat...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238406/ https://www.ncbi.nlm.nih.gov/pubmed/22203919 http://dx.doi.org/10.1155/2012/793076 |
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author | Bogdanova, Yelena Cronin-Golomb, Alice |
author_facet | Bogdanova, Yelena Cronin-Golomb, Alice |
author_sort | Bogdanova, Yelena |
collection | PubMed |
description | Parkinson's disease (PD) is associated with various nonmotor symptoms including neuropsychiatric and cognitive dysfunction. We examined the relation between apathy, anxiety, side of onset of motor symptoms, and cognition in PD. We hypothesized that PD patients would show different neuropsychiatric and neurocognitive profiles depending on the side of onset. 22 nondemented PD patients (11 right-side onset (RPD) with predominant left-hemisphere pathology, and 11 LPD) and 22 matched healthy controls (NC) were administered rating scales assessing apathy and anxiety, and a series of neuropsychological tests. PD patients showed a higher anxiety level than NC. There was a significant association between apathy, anxiety, and disease duration. In LPD, apathy but not anxiety was associated with performance on nonverbally mediated executive function and visuospatial measures, whereas, in RPD, anxiety but not apathy correlated with performance on verbally mediated tasks. Our findings demonstrated a differential association of apathy and anxiety to cognition in PD. |
format | Online Article Text |
id | pubmed-3238406 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-32384062011-12-27 Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease Bogdanova, Yelena Cronin-Golomb, Alice Parkinsons Dis Research Article Parkinson's disease (PD) is associated with various nonmotor symptoms including neuropsychiatric and cognitive dysfunction. We examined the relation between apathy, anxiety, side of onset of motor symptoms, and cognition in PD. We hypothesized that PD patients would show different neuropsychiatric and neurocognitive profiles depending on the side of onset. 22 nondemented PD patients (11 right-side onset (RPD) with predominant left-hemisphere pathology, and 11 LPD) and 22 matched healthy controls (NC) were administered rating scales assessing apathy and anxiety, and a series of neuropsychological tests. PD patients showed a higher anxiety level than NC. There was a significant association between apathy, anxiety, and disease duration. In LPD, apathy but not anxiety was associated with performance on nonverbally mediated executive function and visuospatial measures, whereas, in RPD, anxiety but not apathy correlated with performance on verbally mediated tasks. Our findings demonstrated a differential association of apathy and anxiety to cognition in PD. Hindawi Publishing Corporation 2012 2011-12-12 /pmc/articles/PMC3238406/ /pubmed/22203919 http://dx.doi.org/10.1155/2012/793076 Text en Copyright © 2012 Y. Bogdanova and A. Cronin-Golomb. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Bogdanova, Yelena Cronin-Golomb, Alice Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease |
title | Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease |
title_full | Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease |
title_fullStr | Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease |
title_full_unstemmed | Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease |
title_short | Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease |
title_sort | neurocognitive correlates of apathy and anxiety in parkinson's disease |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238406/ https://www.ncbi.nlm.nih.gov/pubmed/22203919 http://dx.doi.org/10.1155/2012/793076 |
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