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Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease

Parkinson's disease (PD) is associated with various nonmotor symptoms including neuropsychiatric and cognitive dysfunction. We examined the relation between apathy, anxiety, side of onset of motor symptoms, and cognition in PD. We hypothesized that PD patients would show different neuropsychiat...

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Autores principales: Bogdanova, Yelena, Cronin-Golomb, Alice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238406/
https://www.ncbi.nlm.nih.gov/pubmed/22203919
http://dx.doi.org/10.1155/2012/793076
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author Bogdanova, Yelena
Cronin-Golomb, Alice
author_facet Bogdanova, Yelena
Cronin-Golomb, Alice
author_sort Bogdanova, Yelena
collection PubMed
description Parkinson's disease (PD) is associated with various nonmotor symptoms including neuropsychiatric and cognitive dysfunction. We examined the relation between apathy, anxiety, side of onset of motor symptoms, and cognition in PD. We hypothesized that PD patients would show different neuropsychiatric and neurocognitive profiles depending on the side of onset. 22 nondemented PD patients (11 right-side onset (RPD) with predominant left-hemisphere pathology, and 11 LPD) and 22 matched healthy controls (NC) were administered rating scales assessing apathy and anxiety, and a series of neuropsychological tests. PD patients showed a higher anxiety level than NC. There was a significant association between apathy, anxiety, and disease duration. In LPD, apathy but not anxiety was associated with performance on nonverbally mediated executive function and visuospatial measures, whereas, in RPD, anxiety but not apathy correlated with performance on verbally mediated tasks. Our findings demonstrated a differential association of apathy and anxiety to cognition in PD.
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spelling pubmed-32384062011-12-27 Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease Bogdanova, Yelena Cronin-Golomb, Alice Parkinsons Dis Research Article Parkinson's disease (PD) is associated with various nonmotor symptoms including neuropsychiatric and cognitive dysfunction. We examined the relation between apathy, anxiety, side of onset of motor symptoms, and cognition in PD. We hypothesized that PD patients would show different neuropsychiatric and neurocognitive profiles depending on the side of onset. 22 nondemented PD patients (11 right-side onset (RPD) with predominant left-hemisphere pathology, and 11 LPD) and 22 matched healthy controls (NC) were administered rating scales assessing apathy and anxiety, and a series of neuropsychological tests. PD patients showed a higher anxiety level than NC. There was a significant association between apathy, anxiety, and disease duration. In LPD, apathy but not anxiety was associated with performance on nonverbally mediated executive function and visuospatial measures, whereas, in RPD, anxiety but not apathy correlated with performance on verbally mediated tasks. Our findings demonstrated a differential association of apathy and anxiety to cognition in PD. Hindawi Publishing Corporation 2012 2011-12-12 /pmc/articles/PMC3238406/ /pubmed/22203919 http://dx.doi.org/10.1155/2012/793076 Text en Copyright © 2012 Y. Bogdanova and A. Cronin-Golomb. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bogdanova, Yelena
Cronin-Golomb, Alice
Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease
title Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease
title_full Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease
title_fullStr Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease
title_full_unstemmed Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease
title_short Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease
title_sort neurocognitive correlates of apathy and anxiety in parkinson's disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238406/
https://www.ncbi.nlm.nih.gov/pubmed/22203919
http://dx.doi.org/10.1155/2012/793076
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