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Severe isoniazid related sideroblastic anemia

Isoniazid induced sideroblastic anemia is a rare event. We report case of a 45 year old Caucasian women with development of severe anaemia 4 month after introduction of Isoniazid as part of Tuberculosis treatment. While haemoglobin fell to 47 g/L and erythrocyte count to 1.5 G/L, reticulocytes were...

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Autores principales: Piso, Rein Jan, Kriz, Kveti, Desax, Marie-Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PAGEPress Publications 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238472/
https://www.ncbi.nlm.nih.gov/pubmed/22184524
http://dx.doi.org/10.4081/hr.2011.e2
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author Piso, Rein Jan
Kriz, Kveti
Desax, Marie-Claire
author_facet Piso, Rein Jan
Kriz, Kveti
Desax, Marie-Claire
author_sort Piso, Rein Jan
collection PubMed
description Isoniazid induced sideroblastic anemia is a rare event. We report case of a 45 year old Caucasian women with development of severe anaemia 4 month after introduction of Isoniazid as part of Tuberculosis treatment. While haemoglobin fell to 47 g/L and erythrocyte count to 1.5 G/L, reticulocytes were very low (reticulocyte production index of 0.48), but bone marrow aspirate showed an accelerated erythropoiesis with ringsideroblasts. Anaemia rapidly resolved after cessation of Isoniazid. We postulate an Isoniazid induced inhibition of the δ-Amino-levulinat-synthase resulting in marked depletion of heam synthesis.
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spelling pubmed-32384722011-12-19 Severe isoniazid related sideroblastic anemia Piso, Rein Jan Kriz, Kveti Desax, Marie-Claire Hematol Rep Case Report Isoniazid induced sideroblastic anemia is a rare event. We report case of a 45 year old Caucasian women with development of severe anaemia 4 month after introduction of Isoniazid as part of Tuberculosis treatment. While haemoglobin fell to 47 g/L and erythrocyte count to 1.5 G/L, reticulocytes were very low (reticulocyte production index of 0.48), but bone marrow aspirate showed an accelerated erythropoiesis with ringsideroblasts. Anaemia rapidly resolved after cessation of Isoniazid. We postulate an Isoniazid induced inhibition of the δ-Amino-levulinat-synthase resulting in marked depletion of heam synthesis. PAGEPress Publications 2011-01-21 /pmc/articles/PMC3238472/ /pubmed/22184524 http://dx.doi.org/10.4081/hr.2011.e2 Text en ©Copyright R.J. Piso et al., 2011 This work is licensed under a Creative Commons Attribution 3.0 License (by-nc 3.0). Licensee PAGEPress, Italy
spellingShingle Case Report
Piso, Rein Jan
Kriz, Kveti
Desax, Marie-Claire
Severe isoniazid related sideroblastic anemia
title Severe isoniazid related sideroblastic anemia
title_full Severe isoniazid related sideroblastic anemia
title_fullStr Severe isoniazid related sideroblastic anemia
title_full_unstemmed Severe isoniazid related sideroblastic anemia
title_short Severe isoniazid related sideroblastic anemia
title_sort severe isoniazid related sideroblastic anemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238472/
https://www.ncbi.nlm.nih.gov/pubmed/22184524
http://dx.doi.org/10.4081/hr.2011.e2
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