N-(2-Fluoro­phen­yl)-5-[(4-meth­oxy­phen­yl)amino­meth­yl]-6-methyl-2-phenyl­pyrimidin-4-amine

The conformation of the title mol­ecule, C(25)H(23)FN(4)O, is mainly determined by an intra­molecular N—H⋯N hydrogen bond closing a six-membered ring and the dihedral angles between the pyrimidine ring and the three benzene rings which are 12.8 (2), 12.0 (2) and 86.1 (2)°. An intra­molecular N—H⋯F i...

Descripción completa

Detalles Bibliográficos
Autores principales: Cieplik, Jerzy, Pluta, Janusz, Bryndal, Iwona, Lis, Tadeusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238833/
https://www.ncbi.nlm.nih.gov/pubmed/22199686
http://dx.doi.org/10.1107/S1600536811045028
_version_ 1782219065166659584
author Cieplik, Jerzy
Pluta, Janusz
Bryndal, Iwona
Lis, Tadeusz
author_facet Cieplik, Jerzy
Pluta, Janusz
Bryndal, Iwona
Lis, Tadeusz
author_sort Cieplik, Jerzy
collection PubMed
description The conformation of the title mol­ecule, C(25)H(23)FN(4)O, is mainly determined by an intra­molecular N—H⋯N hydrogen bond closing a six-membered ring and the dihedral angles between the pyrimidine ring and the three benzene rings which are 12.8 (2), 12.0 (2) and 86.1 (2)°. An intra­molecular N—H⋯F inter­action also occurs. The crystal stucture is stabilized by weak C—H⋯O and C—H⋯π inter­actions. An inter­molecular N—H⋯N inter­action is also observed.
format Online
Article
Text
id pubmed-3238833
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher International Union of Crystallography
record_format MEDLINE/PubMed
spelling pubmed-32388332011-12-23 N-(2-Fluoro­phen­yl)-5-[(4-meth­oxy­phen­yl)amino­meth­yl]-6-methyl-2-phenyl­pyrimidin-4-amine Cieplik, Jerzy Pluta, Janusz Bryndal, Iwona Lis, Tadeusz Acta Crystallogr Sect E Struct Rep Online Organic Papers The conformation of the title mol­ecule, C(25)H(23)FN(4)O, is mainly determined by an intra­molecular N—H⋯N hydrogen bond closing a six-membered ring and the dihedral angles between the pyrimidine ring and the three benzene rings which are 12.8 (2), 12.0 (2) and 86.1 (2)°. An intra­molecular N—H⋯F inter­action also occurs. The crystal stucture is stabilized by weak C—H⋯O and C—H⋯π inter­actions. An inter­molecular N—H⋯N inter­action is also observed. International Union of Crystallography 2011-11-05 /pmc/articles/PMC3238833/ /pubmed/22199686 http://dx.doi.org/10.1107/S1600536811045028 Text en © Cieplik et al. 2011 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Cieplik, Jerzy
Pluta, Janusz
Bryndal, Iwona
Lis, Tadeusz
N-(2-Fluoro­phen­yl)-5-[(4-meth­oxy­phen­yl)amino­meth­yl]-6-methyl-2-phenyl­pyrimidin-4-amine
title N-(2-Fluoro­phen­yl)-5-[(4-meth­oxy­phen­yl)amino­meth­yl]-6-methyl-2-phenyl­pyrimidin-4-amine
title_full N-(2-Fluoro­phen­yl)-5-[(4-meth­oxy­phen­yl)amino­meth­yl]-6-methyl-2-phenyl­pyrimidin-4-amine
title_fullStr N-(2-Fluoro­phen­yl)-5-[(4-meth­oxy­phen­yl)amino­meth­yl]-6-methyl-2-phenyl­pyrimidin-4-amine
title_full_unstemmed N-(2-Fluoro­phen­yl)-5-[(4-meth­oxy­phen­yl)amino­meth­yl]-6-methyl-2-phenyl­pyrimidin-4-amine
title_short N-(2-Fluoro­phen­yl)-5-[(4-meth­oxy­phen­yl)amino­meth­yl]-6-methyl-2-phenyl­pyrimidin-4-amine
title_sort n-(2-fluoro­phen­yl)-5-[(4-meth­oxy­phen­yl)amino­meth­yl]-6-methyl-2-phenyl­pyrimidin-4-amine
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238833/
https://www.ncbi.nlm.nih.gov/pubmed/22199686
http://dx.doi.org/10.1107/S1600536811045028
work_keys_str_mv AT cieplikjerzy n2fluorophenyl54methoxyphenylaminomethyl6methyl2phenylpyrimidin4amine
AT plutajanusz n2fluorophenyl54methoxyphenylaminomethyl6methyl2phenylpyrimidin4amine
AT bryndaliwona n2fluorophenyl54methoxyphenylaminomethyl6methyl2phenylpyrimidin4amine
AT listadeusz n2fluorophenyl54methoxyphenylaminomethyl6methyl2phenylpyrimidin4amine

Ejemplares similares