tert-Butyl 2-{[2,8-bis­(trifluoro­meth­yl)quinolin-4-yl](hy­droxy)meth­yl}piperidine-1-carboxyl­ate

The title mol­ecule, C(22)H(24)F(6)N(2)O(3), adopts a folded conformation whereby the carboxyl­ate residue lies over the quinolinyl residue, with the dihedral angle between the carbamate and quinoline planes being 41.64 (7)°. Helical supra­molecular C(7) chains sustained by O—H⋯O hydrogen bonds prop...

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Detalles Bibliográficos
Autores principales: Gonçalves, Raoni S. B., de Souza, Marcus V. N., Wardell, James L., Wardell, Solange M. S. V., Tiekink, Edward R. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238966/
https://www.ncbi.nlm.nih.gov/pubmed/22199815
http://dx.doi.org/10.1107/S1600536811047726
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author Gonçalves, Raoni S. B.
de Souza, Marcus V. N.
Wardell, James L.
Wardell, Solange M. S. V.
Tiekink, Edward R. T.
author_facet Gonçalves, Raoni S. B.
de Souza, Marcus V. N.
Wardell, James L.
Wardell, Solange M. S. V.
Tiekink, Edward R. T.
author_sort Gonçalves, Raoni S. B.
collection PubMed
description The title mol­ecule, C(22)H(24)F(6)N(2)O(3), adopts a folded conformation whereby the carboxyl­ate residue lies over the quinolinyl residue, with the dihedral angle between the carbamate and quinoline planes being 41.64 (7)°. Helical supra­molecular C(7) chains sustained by O—H⋯O hydrogen bonds propagating along the a-axis direction feature in the crystal packing. The F atoms of one of the CF(3) groups are disordered over two orientations; the major component has a site occupancy of 0.824 (7).
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spelling pubmed-32389662011-12-23 tert-Butyl 2-{[2,8-bis­(trifluoro­meth­yl)quinolin-4-yl](hy­droxy)meth­yl}piperidine-1-carboxyl­ate Gonçalves, Raoni S. B. de Souza, Marcus V. N. Wardell, James L. Wardell, Solange M. S. V. Tiekink, Edward R. T. Acta Crystallogr Sect E Struct Rep Online Organic Papers The title mol­ecule, C(22)H(24)F(6)N(2)O(3), adopts a folded conformation whereby the carboxyl­ate residue lies over the quinolinyl residue, with the dihedral angle between the carbamate and quinoline planes being 41.64 (7)°. Helical supra­molecular C(7) chains sustained by O—H⋯O hydrogen bonds propagating along the a-axis direction feature in the crystal packing. The F atoms of one of the CF(3) groups are disordered over two orientations; the major component has a site occupancy of 0.824 (7). International Union of Crystallography 2011-11-16 /pmc/articles/PMC3238966/ /pubmed/22199815 http://dx.doi.org/10.1107/S1600536811047726 Text en © Gonçalves et al. 2011 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Gonçalves, Raoni S. B.
de Souza, Marcus V. N.
Wardell, James L.
Wardell, Solange M. S. V.
Tiekink, Edward R. T.
tert-Butyl 2-{[2,8-bis­(trifluoro­meth­yl)quinolin-4-yl](hy­droxy)meth­yl}piperidine-1-carboxyl­ate
title tert-Butyl 2-{[2,8-bis­(trifluoro­meth­yl)quinolin-4-yl](hy­droxy)meth­yl}piperidine-1-carboxyl­ate
title_full tert-Butyl 2-{[2,8-bis­(trifluoro­meth­yl)quinolin-4-yl](hy­droxy)meth­yl}piperidine-1-carboxyl­ate
title_fullStr tert-Butyl 2-{[2,8-bis­(trifluoro­meth­yl)quinolin-4-yl](hy­droxy)meth­yl}piperidine-1-carboxyl­ate
title_full_unstemmed tert-Butyl 2-{[2,8-bis­(trifluoro­meth­yl)quinolin-4-yl](hy­droxy)meth­yl}piperidine-1-carboxyl­ate
title_short tert-Butyl 2-{[2,8-bis­(trifluoro­meth­yl)quinolin-4-yl](hy­droxy)meth­yl}piperidine-1-carboxyl­ate
title_sort tert-butyl 2-{[2,8-bis­(trifluoro­meth­yl)quinolin-4-yl](hy­droxy)meth­yl}piperidine-1-carboxyl­ate
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3238966/
https://www.ncbi.nlm.nih.gov/pubmed/22199815
http://dx.doi.org/10.1107/S1600536811047726
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