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(1R*,3′S*,4′R*)-4′-(4-Chloro­phen­yl)-3′-[(4-hy­droxy-2-oxo-1,2-dihydro­quinolin-3-yl)carbon­yl]-1′-methyl­spiro­[ace­naphthyl­ene-1,2′-pyrrolidin]-2-one

The title compound, C(32)H(23)ClN(2)O(4), has a quinoline, a chloro­phenyl and an acenaphthalene ring system attached to a central pyrrolidine ring, which has three stereogenic centers. Nevertheless, the compound crystallizes as a racemate with two mol­ecules of identical chirality in the asymmetric...

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Detalles Bibliográficos
Autores principales: Vennila, K. N., Sankaran, M., Mohan, P. S., Velmurugan, D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239020/
https://www.ncbi.nlm.nih.gov/pubmed/22199868
http://dx.doi.org/10.1107/S1600536811048896
Descripción
Sumario:The title compound, C(32)H(23)ClN(2)O(4), has a quinoline, a chloro­phenyl and an acenaphthalene ring system attached to a central pyrrolidine ring, which has three stereogenic centers. Nevertheless, the compound crystallizes as a racemate with two mol­ecules of identical chirality in the asymmetric unit. They differ in the conformation of the five-membered pyrrolidine ring; in one molecule it has an envelope conformation, while in the other molecule it has a twisted conformation. In each molecule there is an intra­molecular O—H⋯O hydrogen bond making an S(6) ring motif. In the crystal, pairs of N—H⋯O hydrogen bonds produce inversion dimers with R (2) (2)(8) motifs. There are also C—H⋯O interactions present. The crystal structure contains voids (60 Å(3)) within which there is no evidence of solvent mol­ecules.