4-[(tert-Butyl­dimethyl­sil­yl)­oxy]-6-meth­oxy-7-methyl-5-(oxiran-2-ylmeth­yl)-2-benzofuran-3(1H)-one

The title compound, C(19)H(28)O(5)Si, was obtained in the reaction of 1,3-dihydro-4-[(tert-butyl­dimethyl­sil­yl)­oxy]-6-meth­oxy-7-methyl-3-oxo-5-(prop-2-en­yl)isobenzofuran with meta-chloro­perbenzoic acid. This reaction is one of the stages of the total synthesis of mycophenolic acid, which we at...

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Detalles Bibliográficos
Autores principales: Malachowska-Ugarte, Magdalena, Cholewinski, Grzegorz, Chojnacki, Jaroslaw, Dzierzbicka, Krystyna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239034/
https://www.ncbi.nlm.nih.gov/pubmed/22199882
http://dx.doi.org/10.1107/S1600536811049026
Descripción
Sumario:The title compound, C(19)H(28)O(5)Si, was obtained in the reaction of 1,3-dihydro-4-[(tert-butyl­dimethyl­sil­yl)­oxy]-6-meth­oxy-7-methyl-3-oxo-5-(prop-2-en­yl)isobenzofuran with meta-chloro­perbenzoic acid. This reaction is one of the stages of the total synthesis of mycophenolic acid, which we attempted to modify. The title compound forms crystals with only weak inter­molecular inter­actions. The strongest stacking inter­action is found between the benzene and furan rings of inversion-related mol­ecules with a distance of 3.8773 (13) Å between the ring centroids.

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