rac-4-{(E)-[1-Cyano-1-cyclo­hexyl-2-(1H-indol-3-yl)eth­yl]imino­meth­yl}benzonitrile

A phosphine-catalysed addition of gramine to an alkyl­idene­amino­nitrile gives the title compound, C(25)H(24)N(4), in good yield. In the crystal, pairs of mol­ecules are connected via N—H⋯N hydrogen bonds into inversion dimers. The mol­ecules are characterized by a planar indole moiety [maximum dev...

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Detalles Bibliográficos
Autores principales: Letessier, Julien, Schollmeyer, Dieter, Detert, Heiner, Opatz, Till
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Organic Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239068/
https://www.ncbi.nlm.nih.gov/pubmed/22199916
http://dx.doi.org/10.1107/S1600536811049841
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author Letessier, Julien
Schollmeyer, Dieter
Detert, Heiner
Opatz, Till
author_facet Letessier, Julien
Schollmeyer, Dieter
Detert, Heiner
Opatz, Till
author_sort Letessier, Julien
collection PubMed
description A phosphine-catalysed addition of gramine to an alkyl­idene­amino­nitrile gives the title compound, C(25)H(24)N(4), in good yield. In the crystal, pairs of mol­ecules are connected via N—H⋯N hydrogen bonds into inversion dimers. The mol­ecules are characterized by a planar indole moiety [maximum deviation = 0.012 (1) Å], a chair conformation of the cyclo­hexane ring and an anti­periplanar conformation of the H atom on the cyclo­hexane and the adjacent cyano group.
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spelling pubmed-32390682011-12-23 rac-4-{(E)-[1-Cyano-1-cyclo­hexyl-2-(1H-indol-3-yl)eth­yl]imino­meth­yl}benzonitrile Letessier, Julien Schollmeyer, Dieter Detert, Heiner Opatz, Till Acta Crystallogr Sect E Struct Rep Online Organic Papers A phosphine-catalysed addition of gramine to an alkyl­idene­amino­nitrile gives the title compound, C(25)H(24)N(4), in good yield. In the crystal, pairs of mol­ecules are connected via N—H⋯N hydrogen bonds into inversion dimers. The mol­ecules are characterized by a planar indole moiety [maximum deviation = 0.012 (1) Å], a chair conformation of the cyclo­hexane ring and an anti­periplanar conformation of the H atom on the cyclo­hexane and the adjacent cyano group. International Union of Crystallography 2011-11-25 /pmc/articles/PMC3239068/ /pubmed/22199916 http://dx.doi.org/10.1107/S1600536811049841 Text en © Letessier et al. 2011 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Letessier, Julien
Schollmeyer, Dieter
Detert, Heiner
Opatz, Till
rac-4-{(E)-[1-Cyano-1-cyclo­hexyl-2-(1H-indol-3-yl)eth­yl]imino­meth­yl}benzonitrile
title rac-4-{(E)-[1-Cyano-1-cyclo­hexyl-2-(1H-indol-3-yl)eth­yl]imino­meth­yl}benzonitrile
title_full rac-4-{(E)-[1-Cyano-1-cyclo­hexyl-2-(1H-indol-3-yl)eth­yl]imino­meth­yl}benzonitrile
title_fullStr rac-4-{(E)-[1-Cyano-1-cyclo­hexyl-2-(1H-indol-3-yl)eth­yl]imino­meth­yl}benzonitrile
title_full_unstemmed rac-4-{(E)-[1-Cyano-1-cyclo­hexyl-2-(1H-indol-3-yl)eth­yl]imino­meth­yl}benzonitrile
title_short rac-4-{(E)-[1-Cyano-1-cyclo­hexyl-2-(1H-indol-3-yl)eth­yl]imino­meth­yl}benzonitrile
title_sort rac-4-{(e)-[1-cyano-1-cyclo­hexyl-2-(1h-indol-3-yl)eth­yl]imino­meth­yl}benzonitrile
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239068/
https://www.ncbi.nlm.nih.gov/pubmed/22199916
http://dx.doi.org/10.1107/S1600536811049841
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