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Methyl 5-(4-hydroxy-3-methoxyphenyl)-2-(4-methoxybenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate
In the title compound, C(24)H(22)N(2)O(6)S, a pyrimidine ring substituted with 4-hydroxy-3-methoxyphenyl is fused with a thiazole ring. The 4-hydroxy-3-methoxyphenyl group is positioned axially to the pyrimidine ring, making a dihedral angle 85.36 (7)°. The pyrimidine ring adopts a twist boat...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239076/ https://www.ncbi.nlm.nih.gov/pubmed/22199924 http://dx.doi.org/10.1107/S1600536811048987 |
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author | Nagarajaiah, H. Begum, Noor Shahina |
author_facet | Nagarajaiah, H. Begum, Noor Shahina |
author_sort | Nagarajaiah, H. |
collection | PubMed |
description | In the title compound, C(24)H(22)N(2)O(6)S, a pyrimidine ring substituted with 4-hydroxy-3-methoxyphenyl is fused with a thiazole ring. The 4-hydroxy-3-methoxyphenyl group is positioned axially to the pyrimidine ring, making a dihedral angle 85.36 (7)°. The pyrimidine ring adopts a twist boat conformation. In the crystal, O—H⋯N interactions result in a chain running along the b axis. The carbonyl O atom bonded to the thiazole ring is involved in two C—H⋯O hydrogen-bond interactions forming centrosymmetric dimers; the ten- and six-membered rings resulting from these interactions have R (2) (2)(10) and R (1) (2)(6) motifs, respectively. |
format | Online Article Text |
id | pubmed-3239076 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-32390762011-12-23 Methyl 5-(4-hydroxy-3-methoxyphenyl)-2-(4-methoxybenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate Nagarajaiah, H. Begum, Noor Shahina Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(24)H(22)N(2)O(6)S, a pyrimidine ring substituted with 4-hydroxy-3-methoxyphenyl is fused with a thiazole ring. The 4-hydroxy-3-methoxyphenyl group is positioned axially to the pyrimidine ring, making a dihedral angle 85.36 (7)°. The pyrimidine ring adopts a twist boat conformation. In the crystal, O—H⋯N interactions result in a chain running along the b axis. The carbonyl O atom bonded to the thiazole ring is involved in two C—H⋯O hydrogen-bond interactions forming centrosymmetric dimers; the ten- and six-membered rings resulting from these interactions have R (2) (2)(10) and R (1) (2)(6) motifs, respectively. International Union of Crystallography 2011-11-25 /pmc/articles/PMC3239076/ /pubmed/22199924 http://dx.doi.org/10.1107/S1600536811048987 Text en © Nagarajaiah and Begum 2011 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Nagarajaiah, H. Begum, Noor Shahina Methyl 5-(4-hydroxy-3-methoxyphenyl)-2-(4-methoxybenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate |
title | Methyl 5-(4-hydroxy-3-methoxyphenyl)-2-(4-methoxybenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate |
title_full | Methyl 5-(4-hydroxy-3-methoxyphenyl)-2-(4-methoxybenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate |
title_fullStr | Methyl 5-(4-hydroxy-3-methoxyphenyl)-2-(4-methoxybenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate |
title_full_unstemmed | Methyl 5-(4-hydroxy-3-methoxyphenyl)-2-(4-methoxybenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate |
title_short | Methyl 5-(4-hydroxy-3-methoxyphenyl)-2-(4-methoxybenzylidene)-7-methyl-3-oxo-2,3-dihydro-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate |
title_sort | methyl 5-(4-hydroxy-3-methoxyphenyl)-2-(4-methoxybenzylidene)-7-methyl-3-oxo-2,3-dihydro-5h-thiazolo[3,2-a]pyrimidine-6-carboxylate |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239076/ https://www.ncbi.nlm.nih.gov/pubmed/22199924 http://dx.doi.org/10.1107/S1600536811048987 |
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