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3-[4-(10H-Indolo[3,2-b]quinolin-11-yl)piperazin-1-yl]propan-1-ol
In the title compound, C(22)H(24)N(4)O, the aromatic moiety is essentially planar (r.m.s. deviation of a least-squares plane fitted through all non-H atoms = 0.0386 Å) and is rotated by 89.98 (4)° from the piperazine ring, which adopts the expected chair conformation. The propanol chain is not fully...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239093/ https://www.ncbi.nlm.nih.gov/pubmed/22199941 http://dx.doi.org/10.1107/S1600536811050215 |
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author | Nichol, Gary S. Boddupally, Peda V. L. De, Biswanath Hurley, Laurence H. |
author_facet | Nichol, Gary S. Boddupally, Peda V. L. De, Biswanath Hurley, Laurence H. |
author_sort | Nichol, Gary S. |
collection | PubMed |
description | In the title compound, C(22)H(24)N(4)O, the aromatic moiety is essentially planar (r.m.s. deviation of a least-squares plane fitted through all non-H atoms = 0.0386 Å) and is rotated by 89.98 (4)° from the piperazine ring, which adopts the expected chair conformation. The propanol chain is not fully extended away from the piperazine ring. In the crystal, there are two unique hydrogen-bonding interactions. One is an O—H⋯N interaction which, together with an inversion-related symmetry equivalent, forms a ring motif. The second is an N—H⋯N interaction which links adjacent molecules by means of a chain motif which propagates in the c-axis direction. Overall, a two-dimensional hydrogen-bonded structure is formed. |
format | Online Article Text |
id | pubmed-3239093 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | International Union of Crystallography |
record_format | MEDLINE/PubMed |
spelling | pubmed-32390932011-12-23 3-[4-(10H-Indolo[3,2-b]quinolin-11-yl)piperazin-1-yl]propan-1-ol Nichol, Gary S. Boddupally, Peda V. L. De, Biswanath Hurley, Laurence H. Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(22)H(24)N(4)O, the aromatic moiety is essentially planar (r.m.s. deviation of a least-squares plane fitted through all non-H atoms = 0.0386 Å) and is rotated by 89.98 (4)° from the piperazine ring, which adopts the expected chair conformation. The propanol chain is not fully extended away from the piperazine ring. In the crystal, there are two unique hydrogen-bonding interactions. One is an O—H⋯N interaction which, together with an inversion-related symmetry equivalent, forms a ring motif. The second is an N—H⋯N interaction which links adjacent molecules by means of a chain motif which propagates in the c-axis direction. Overall, a two-dimensional hydrogen-bonded structure is formed. International Union of Crystallography 2011-11-30 /pmc/articles/PMC3239093/ /pubmed/22199941 http://dx.doi.org/10.1107/S1600536811050215 Text en © Nichol et al. 2011 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited. |
spellingShingle | Organic Papers Nichol, Gary S. Boddupally, Peda V. L. De, Biswanath Hurley, Laurence H. 3-[4-(10H-Indolo[3,2-b]quinolin-11-yl)piperazin-1-yl]propan-1-ol |
title | 3-[4-(10H-Indolo[3,2-b]quinolin-11-yl)piperazin-1-yl]propan-1-ol |
title_full | 3-[4-(10H-Indolo[3,2-b]quinolin-11-yl)piperazin-1-yl]propan-1-ol |
title_fullStr | 3-[4-(10H-Indolo[3,2-b]quinolin-11-yl)piperazin-1-yl]propan-1-ol |
title_full_unstemmed | 3-[4-(10H-Indolo[3,2-b]quinolin-11-yl)piperazin-1-yl]propan-1-ol |
title_short | 3-[4-(10H-Indolo[3,2-b]quinolin-11-yl)piperazin-1-yl]propan-1-ol |
title_sort | 3-[4-(10h-indolo[3,2-b]quinolin-11-yl)piperazin-1-yl]propan-1-ol |
topic | Organic Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239093/ https://www.ncbi.nlm.nih.gov/pubmed/22199941 http://dx.doi.org/10.1107/S1600536811050215 |
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