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3-[4-(10H-Indolo[3,2-b]quinolin-11-yl)piperazin-1-yl]propan-1-ol

In the title compound, C(22)H(24)N(4)O, the aromatic moiety is essentially planar (r.m.s. deviation of a least-squares plane fitted through all non-H atoms = 0.0386 Å) and is rotated by 89.98 (4)° from the piperazine ring, which adopts the expected chair conformation. The propanol chain is not fully...

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Detalles Bibliográficos
Autores principales: Nichol, Gary S., Boddupally, Peda V. L., De, Biswanath, Hurley, Laurence H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239093/
https://www.ncbi.nlm.nih.gov/pubmed/22199941
http://dx.doi.org/10.1107/S1600536811050215
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author Nichol, Gary S.
Boddupally, Peda V. L.
De, Biswanath
Hurley, Laurence H.
author_facet Nichol, Gary S.
Boddupally, Peda V. L.
De, Biswanath
Hurley, Laurence H.
author_sort Nichol, Gary S.
collection PubMed
description In the title compound, C(22)H(24)N(4)O, the aromatic moiety is essentially planar (r.m.s. deviation of a least-squares plane fitted through all non-H atoms = 0.0386 Å) and is rotated by 89.98 (4)° from the piperazine ring, which adopts the expected chair conformation. The propanol chain is not fully extended away from the piperazine ring. In the crystal, there are two unique hydrogen-bonding inter­actions. One is an O—H⋯N inter­action which, together with an inversion-related symmetry equivalent, forms a ring motif. The second is an N—H⋯N inter­action which links adjacent mol­ecules by means of a chain motif which propagates in the c-axis direction. Overall, a two-dimensional hydrogen-bonded structure is formed.
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spelling pubmed-32390932011-12-23 3-[4-(10H-Indolo[3,2-b]quinolin-11-yl)piperazin-1-yl]propan-1-ol Nichol, Gary S. Boddupally, Peda V. L. De, Biswanath Hurley, Laurence H. Acta Crystallogr Sect E Struct Rep Online Organic Papers In the title compound, C(22)H(24)N(4)O, the aromatic moiety is essentially planar (r.m.s. deviation of a least-squares plane fitted through all non-H atoms = 0.0386 Å) and is rotated by 89.98 (4)° from the piperazine ring, which adopts the expected chair conformation. The propanol chain is not fully extended away from the piperazine ring. In the crystal, there are two unique hydrogen-bonding inter­actions. One is an O—H⋯N inter­action which, together with an inversion-related symmetry equivalent, forms a ring motif. The second is an N—H⋯N inter­action which links adjacent mol­ecules by means of a chain motif which propagates in the c-axis direction. Overall, a two-dimensional hydrogen-bonded structure is formed. International Union of Crystallography 2011-11-30 /pmc/articles/PMC3239093/ /pubmed/22199941 http://dx.doi.org/10.1107/S1600536811050215 Text en © Nichol et al. 2011 http://creativecommons.org/licenses/by/2.0/uk/ This is an open-access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Organic Papers
Nichol, Gary S.
Boddupally, Peda V. L.
De, Biswanath
Hurley, Laurence H.
3-[4-(10H-Indolo[3,2-b]quinolin-11-yl)piperazin-1-yl]propan-1-ol
title 3-[4-(10H-Indolo[3,2-b]quinolin-11-yl)piperazin-1-yl]propan-1-ol
title_full 3-[4-(10H-Indolo[3,2-b]quinolin-11-yl)piperazin-1-yl]propan-1-ol
title_fullStr 3-[4-(10H-Indolo[3,2-b]quinolin-11-yl)piperazin-1-yl]propan-1-ol
title_full_unstemmed 3-[4-(10H-Indolo[3,2-b]quinolin-11-yl)piperazin-1-yl]propan-1-ol
title_short 3-[4-(10H-Indolo[3,2-b]quinolin-11-yl)piperazin-1-yl]propan-1-ol
title_sort 3-[4-(10h-indolo[3,2-b]quinolin-11-yl)piperazin-1-yl]propan-1-ol
topic Organic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239093/
https://www.ncbi.nlm.nih.gov/pubmed/22199941
http://dx.doi.org/10.1107/S1600536811050215
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