Myc and PI3K/AKT signaling cooperatively repress FOXO3a-dependent PUMA and GADD45a gene expression

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Growth factor withdrawal inhibits cell cycle progression by stimulating expression of growth-arresting genes through the activation of Forkhead box O transcription factors such as FOXO3a, which binds to the FHRE-responsive elements of a number of target genes such as PUMA and GADD45a. Following expo...

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Detalles Bibliográficos
Autores principales: Amente, Stefano, Zhang, Jiyuan, Lubrano Lavadera, Miriam, Lania, Luigi, Avvedimento, Enrico Vittorio, Majello, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239183/
https://www.ncbi.nlm.nih.gov/pubmed/21835778
http://dx.doi.org/10.1093/nar/gkr638

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