Treatment of breast cancer cells with DNA demethylating agents leads to a release of Pol II stalling at genes with DNA-hypermethylated regions upstream of TSS

Inactivation of tumor suppressor genes plays an important role in tumorigenesis, and epigenetic modifications such as DNA methylation are frequently associated with transcriptional repression. Here, we show that gene silencing at selected genes with signs of DNA hypermethylation in breast cancer cel...

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Detalles Bibliográficos
Autores principales: Tao, Yongguang, Liu, Shuang, Briones, Victorino, Geiman, Theresa M., Muegge, Kathrin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239205/
https://www.ncbi.nlm.nih.gov/pubmed/21880597
http://dx.doi.org/10.1093/nar/gkr611

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