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A randomized, double-blind study of AMG 108 (a fully human monoclonal antibody to IL-1R1) in patients with osteoarthritis of the knee

INTRODUCTION: AMG 108 is a fully human, immunoglobulin subclass G2 (IgG2) monoclonal antibody that binds the human interleukin-1 (IL-1) receptor type 1, inhibiting the activity of IL-1a and IL-1b. In preclinical studies, IL-1 inhibition was shown to be beneficial in models of osteoarthritis (OA). Th...

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Detalles Bibliográficos
Autores principales:	Cohen, Stanley B, Proudman, Susanna, Kivitz, Alan J, Burch, Francis X, Donohue, John P, Burstein, Deborah, Sun, Yu-Nien, Banfield, Christopher, Vincent, Michael S, Ni, Liyun, Zack, Debra J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239365/ https://www.ncbi.nlm.nih.gov/pubmed/21801403 http://dx.doi.org/10.1186/ar3430

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