Decreased catalytic function with altered sumoylation of DNA topoisomerase I in the nuclei of scleroderma fibroblasts

INTRODUCTION: Sumoylation is involved in nucleolus-nucleoplasm transport of DNA topoisomerase I (topo I), which may associate with changes of cellular and topo I functions. Skin fibroblasts of patients with systemic sclerosis (SSc) exhibit profibrotic cellular changes. The aims of this study were to...

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Detalles Bibliográficos
Autores principales: Zhou, Xiaodong, Lin, Wei, Tan, Filemon K, Assassi, Shervin, Fritzler, Mavin J, Guo, Xinjian, Sharif, Roozbeh, Xia, Tom, Lai, Syeling, Arnett, Frank C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3239368/
https://www.ncbi.nlm.nih.gov/pubmed/21827649
http://dx.doi.org/10.1186/ar3435

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